Duweb G, Alhaddar J, Elsherif B, Eljehawi N, Makhlouf H
Dermatology Department, Faculty of Medicine, Garyounis University, Benghazi, Libya.
Drugs Exp Clin Res. 2005;31(5-6):175-9.
Of 17 patients (10 men and 7 women) with psoriasis vulgaris, aged between 12 and 59 years, included in this study, 4 patients were excluded (3 because of a treatment follow-up irregularity and 1 due to severe irritation). Thirteen patients completed the 6-week treatment course where each patient was instructed to apply calcipotriol-betamethasone ointment on the right side and calcipotriol ointment on the left side. The treatment effect was assessed according to the psoriasis area severity index (PASI) changes, and complete blood count and serum calcium was done prior to and at the end of the treatment. Results showed that both sides had improved by 92.3%, with a marked reduction in the mean PASI (from 11.5 to 2.2); a better reduction was observed in the right side during the second and third visits. A marked improvement to complete clearance was seen in 84.6% in calcipotriol-betamethasone side and 76.9% in calcipotriol alone. Mild irritation was reported in the left side in 15.4% which was tolerated with the continuation of treatment application. No telangiectasia or atrophy was observed on the right side. In conclusion, calcipotriol-betamethasone may be recommended in the early weeks of the treatment of psoriasis vulgaris, and it is helpful in psoriasis patients with irritation to calcipotriol alone.
本研究纳入了17例寻常型银屑病患者（10例男性，7例女性），年龄在12至59岁之间，其中4例患者被排除（3例因治疗随访不规律，1例因严重刺激）。13例患者完成了为期6周的治疗疗程，每位患者被指示在右侧涂抹卡泊三醇倍他米松软膏，在左侧涂抹卡泊三醇软膏。根据银屑病面积严重性指数（PASI）变化评估治疗效果，并在治疗前和治疗结束时进行全血细胞计数和血清钙检测。结果显示，两侧均改善了92.3%，平均PASI显著降低（从11.5降至2.2）；在第二次和第三次就诊时，右侧的改善更为明显。卡泊三醇倍他米松一侧有84.6%显著改善至完全清除，单用卡泊三醇一侧为76.9%。左侧有15.4%报告有轻度刺激，继续治疗应用时可耐受。右侧未观察到毛细血管扩张或萎缩。总之，在寻常型银屑病治疗的早期几周可推荐使用卡泊三醇倍他米松，对单用卡泊三醇有刺激的银屑病患者有帮助。
