Thomalla Götz, Kucinski Thomas, Weiller Cornelius, Röther Joachim
Klinik und Poliklinik für Neurologie, Universitätsiklinikum Hamburg-Eppendorf, Hamburg, Germany.
World J Biol Psychiatry. 2006;7(1):56-8. doi: 10.1080/15622970510029966.
Methylphenidate is structurally and functionally similar to amphetamine. Cerebral vasculitis associated with amphetamine abuse is well documented, and in rare cases ischaemic stroke has been reported after methylphenidate intake in children. We report the case of a 63-year-old female who was treated with methylphenidate due to hyperactivity and suffered from multiple ischaemic strokes. We consider drug-induced cerebral vasculitis as the most likely cause of recurrent ischaemic strokes in the absence of any pathological findings during the diagnostic work-up. We conclude that methylphenidate mediated vasculitis should be considered in patients with neurological symptoms and a history of methylphenidate therapy. This potential side-effect, though very rare, represents one more reason to be very restrictive in the use of methylphenidate.
哌甲酯在结构和功能上与苯丙胺相似。与苯丙胺滥用相关的脑血管炎已有充分记录，在罕见情况下，儿童服用哌甲酯后曾有缺血性中风的报告。我们报告了一例63岁女性患者，因多动接受哌甲酯治疗后发生多次缺血性中风。在诊断检查未发现任何病理结果的情况下，我们认为药物性脑血管炎是复发性缺血性中风最可能的原因。我们得出结论，对于有神经症状且有哌甲酯治疗史的患者，应考虑哌甲酯介导的血管炎。这种潜在的副作用虽然非常罕见，但却是哌甲酯使用应极为严格限制的又一个原因。
