Kiesslich R, Hoffman A, Neurath M F
Dept. of Medicine I, Johannes Gutenberg University, Mainz, Germany. ralf-kiesslich.de
Endoscopy. 2006 Jan;38(1):5-10. doi: 10.1055/s-2005-921122.
Accurate detection of premalignant lesions and early cancers in the colon is essential for curative endoscopic or surgical therapy, since the prognosis for the affected patients is closely related to the size and stage of the neoplastic lesion. Total colonoscopy is the accepted gold standard for screening and surveillance of colorectal cancer. This review summarizes recently published diagnostic developments and key findings in the areas of colonoscopy, colonic tumors, and inflammatory bowel diseases. Relevant findings have been reported for chromo-endoscopy in the diagnosis of colitis-associated neoplasia, as well as flat and depressed adenomas. Real-time Doppler capabilities have now been added to endoscopic optical coherence tomography; the results of large-scale testing of narrow-band imaging endoscopy in the colon are being awaited; and fluorescence imaging has recently been added to the facilities available in video endoscopy. Most importantly, endomicroscopy now for the first time allows single-cell subsurface imaging during ongoing colonoscopy procedures, opening the way to in-vivo molecular and functional imaging.
准确检测结肠的癌前病变和早期癌症对于根治性内镜或手术治疗至关重要，因为受影响患者的预后与肿瘤病变的大小和阶段密切相关。全结肠镜检查是公认的结直肠癌筛查和监测的金标准。本综述总结了最近发表的在结肠镜检查、结肠肿瘤和炎症性肠病领域的诊断进展和关键发现。已经报道了染色内镜在诊断结肠炎相关肿瘤以及扁平型和凹陷型腺瘤方面的相关发现。内镜光学相干断层扫描现已具备实时多普勒功能；结肠窄带成像内镜的大规模测试结果正在等待中；荧光成像最近已添加到视频内镜可用设备中。最重要的是，内镜显微镜现在首次允许在正在进行的结肠镜检查过程中进行单细胞亚表面成像，为体内分子和功能成像开辟了道路。
