Khalil Eltahir Awad G, Ahmed Ammar E, Musa Ahmed M, Hussein Muna H
Department of Clinical Pathology and Immunology. Institute of Endemic Diseases, University of Khartoum, PO Box 45235, Khartoum, Sudan.
Saudi Med J. 2006 Jan;27(1):90-2.
Visceral leishmaniasis VL, caused by Leishmania donovani is endemic over several parts of Sudan. The disease is fatal if not treated. Although sodium stibogluconate Pentostam, a pentavalent antimonial is not free from toxicity, it has been in use for treatment of VL for the last 50 years. Like other infectious diseases, neurological manifestations of VL and sodium stibogluconate have been documented. In this report, we present 2 cases of cerebellar ataxia most likely induced by Pentostam, and explain the probable cause.
内脏利什曼病（VL）由杜氏利什曼原虫引起，在苏丹的多个地区流行。该疾病若不治疗会致命。尽管五价锑化合物葡萄糖酸锑钠（喷他脒）并非没有毒性，但在过去50年里一直用于治疗VL。与其他传染病一样，VL和葡萄糖酸锑钠的神经学表现已有文献记载。在本报告中，我们呈现了2例很可能由喷他脒诱发的小脑共济失调病例，并解释了可能的病因。
