Laboratory of Cell Biology, Department of Microscopy, Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal.
Unit for Multidisciplinary Research in Biomedicine (UMIB)/Laboratory for Integrative and Translational Research in Population Health (ITR), Porto, Portugal.
JBRA Assist Reprod. 2023 Mar 30;27(1):97-111. doi: 10.5935/1518-0557.20220000.
The development of assisted reproductive technology has allowed offspring in infertile couples, and specifically, allowed infertile men to conceive through Intracytoplasmic Sperm Injection (ICSI). Despite the proven efficacy of In Vitro Fertilisation (IVF) and ICSI, many factors can influence its success. In this review we present an analysis on the effect of Female age, Ovarian Reserve, Male age and Male factor on the outcomes of IVF/ICSI, to determine if and which can be applied to the practical context. A literature search on PubMed, EMBASE and MEDLINE for relevant articles was elaborated until July 2021, leading to the selection of 234 articles based on their titles. After reading through the abstracts, those that evaluated IVF/ICSI predicting factors were selected. Finally, only those approaching female age, ovarian reserve, male age and male factor were considered in this review. Higher female age and baseline ovarian markers alterations such as lower anti-Müllerian hormone and antral follicular count, and higher basal follicle-stimulating hormone, were associated with poorer outcomes. The predictive value of Male age and Male factor presented varied results across literature. The multifactorial nature of male fertility makes evaluation difficult. Although the first assessment of male infertility is based on sperm concentration, motility and morphology, semen parameters have shown low prognostic value, whilst sperm DNA alterations gain importance. Nevertheless, results remain controversial. While some factors have proven to predict IVF/ICSI success, other need to be further studied to be applied to practical context to allow the best prognosis possible.
辅助生殖技术的发展使不孕夫妇有了后代，特别是使不孕男性能够通过胞浆内单精子注射（ICSI）受孕。尽管体外受精（IVF）和 ICSI 的疗效已得到证实，但许多因素会影响其成功率。在这篇综述中，我们对女性年龄、卵巢储备、男性年龄和男性因素对 IVF/ICSI 结果的影响进行了分析，以确定哪些因素可以应用于实际情况。我们在 PubMed、EMBASE 和 MEDLINE 上进行了相关文献的检索，直到 2021 年 7 月，根据标题筛选出 234 篇文章。在阅读了摘要之后，我们选择了评估 IVF/ICSI 预测因素的文章。最后，只有那些涉及女性年龄、卵巢储备、男性年龄和男性因素的文章才被纳入本综述。较高的女性年龄和基线卵巢标志物改变，如较低的抗苗勒管激素和窦卵泡计数，以及较高的基础卵泡刺激素，与较差的结局相关。男性年龄和男性因素的预测价值在文献中呈现出不同的结果。男性生育力的多因素性质使得评估变得困难。尽管男性不育的初步评估基于精子浓度、活力和形态，但精液参数显示出低预后价值，而精子 DNA 改变变得重要。然而，结果仍然存在争议。虽然一些因素已被证明可预测 IVF/ICSI 的成功，但其他因素需要进一步研究，才能应用于实际情况，以实现最佳预后。
