Ojewole John A O, Drewes Siegfried E, Khan Fatima
Department of Pharmacology, School of Pharmacy and Pharmacology, Faculty of Health Sciences, University of KwaZulu-Natal, Private Bag X54001, Scottsville, Durban 4000, South Africa.
Phytochemistry. 2006 Mar;67(6):610-7. doi: 10.1016/j.phytochem.2005.11.019. Epub 2006 Jan 24.
Zulu traditional health practitioners have claimed that the roots of Eriosema kraussianum N. E. Br. (Fabaceae) and other Eriosema species (Zulu indigenous umbrella name of "uBangalala") are effective remedies for the treatment of erectile dysfunction (ED) and/or impotence. In order to scientifically appraise the significance and contribution of Eriosema kraussianum to its ethnomedical use as "uBangalala" and "VIAGRA substitute", the present study was undertaken to investigate the vasodilatory and hypoglycaemic properties of the two main bioactive chemical compounds obtained from E. kraussianum, in experimental rat models, using sildenafil citrate (VIAGRA) as the reference drug for comparison. The two E. kraussianum rootstock constituents (K1 and K2, 20-80 mg/kg p.o.) caused dose-dependent and significant (P<0.05-0.001) hypoglycaemia in rats. Relatively low to high concentrations of the plant's extracts (K1 and K2, 100-2000 microg/ml) always produced biphasic effects on rat isolated portal veins. K1- and K2-provoked responses of the isolated portal veins always consisted of concentration-related initial transient, but significant (P<0.05), contractions of the venous muscle preparations, followed by secondary, longer-lasting, highly significant (P<0.01-0.001) relaxations of the venous muscle strips. Sildenafil citrate (VIAGRA, 5-100 microg/ml) always produced concentration-related and highly significant relaxations of the rat isolated portal veins. Unlike K1 and K2 (20-80 mg/kg p.o.), however, sildenafil citrate (VIAGRA, 100 mg/kg p. o.) only caused slight and insignificant (P>0.05) reductions in the blood glucose levels of the experimental animals used. On the other hand, glibenclamide (10 mg/kg p.o.) induced highly significant (P<0.05-0.001), marked reductions in the blood glucose concentrations of the rats. The findings of this laboratory animal study indicate that the two hydro-ethanol extractives of E. kraussianum (K1 and K2) possess hypoglycaemic and secondary, vasorelaxant effects in the experimental paradigms used.
祖鲁族传统医疗从业者宣称，克劳氏毛瓣花（豆科）及其他毛瓣花属物种（祖鲁族本土统称“uBangalala”）的根是治疗勃起功能障碍（ED）和/或阳痿的有效药物。为了科学评估克劳氏毛瓣花作为“uBangalala”和“伟哥替代品”在民族医学应用中的重要性和贡献，本研究使用枸橼酸西地那非（伟哥）作为对照药物，在实验大鼠模型中研究了从克劳氏毛瓣花中提取的两种主要生物活性化合物的血管舒张和降血糖特性。克劳氏毛瓣花的两种根茎成分（K1和K2，口服剂量为20 - 80毫克/千克）在大鼠中引起剂量依赖性且显著的（P<0.05 - 0.001）低血糖。相对低至高浓度的植物提取物（K1和K2，100 - 2000微克/毫升）对大鼠离体门静脉总是产生双相作用。K1和K2引起的离体门静脉反应总是包括与浓度相关的初始短暂但显著的（P<0.05）静脉肌制备物收缩，随后是继发性、持续时间更长、高度显著的（P<0.01 - 0.001）静脉肌条舒张。枸橼酸西地那非（伟哥，5 - 100微克/毫升）总是对大鼠离体门静脉产生与浓度相关的高度显著舒张作用。然而，与K1和K2（口服剂量为20 - 80毫克/千克）不同，枸橼酸西地那非（伟哥，口服剂量为100毫克/千克）仅使所用实验动物的血糖水平略有降低且不显著（P>0.05）。另一方面，格列本脲（口服剂量为10毫克/千克）引起大鼠血糖浓度高度显著的（P<0.05 - 0.001）、明显降低。这项实验动物研究的结果表明，克劳氏毛瓣花的两种水乙醇提取物（K
