Ding J W, Andersson R, Stenram U, Lunderquist A, Bengmark S
Department of Surgery, Lund University, Sweden.
Br J Surg. 1992 Jul;79(7):648-52. doi: 10.1002/bjs.1800790718.
The recovery of reticuloendothelial system (RES) function following decompression of obstructive jaundice was studied using a rat model with bile duct ligation and side-to-side choledochoduodenostomy. Histopathological changes in the liver were still present 5 weeks after relief of jaundice, while results of liver function tests had returned to normal. RES function evaluated by the blood clearance and organ uptake of radiolabelled Escherichia coli using a corrected phagocytic index gradually returned to normal following biliary decompression. The severely impaired RES activity noted 1 week after operation may explain the increased incidence of sepsis and renal insufficiency in the early period after biliary surgery in jaundiced patients.
使用胆管结扎和胆总管十二指肠侧侧吻合术的大鼠模型，研究了梗阻性黄疸减压后网状内皮系统（RES）功能的恢复情况。黄疸缓解5周后，肝脏的组织病理学变化仍然存在，而肝功能测试结果已恢复正常。通过使用校正吞噬指数的放射性标记大肠杆菌的血液清除率和器官摄取来评估的RES功能在胆道减压后逐渐恢复正常。术后1周观察到的严重受损的RES活性可能解释了黄疸患者胆道手术后早期败血症和肾功能不全发生率增加的原因。
