人β-防御素3对多重耐药医院菌株的体外杀菌活性
In vitro bactericidal activity of human beta-defensin 3 against multidrug-resistant nosocomial strains.
作者信息
Maisetta Giuseppantonio, Batoni Giovanna, Esin Semih, Florio Walter, Bottai Daria, Favilli Flavia, Campa Mario
机构信息
Dipartimento di Patologia Sperimentale, Biotecnologie Mediche, Infettivologia ed Epidemiologia, University of Pisa, Pisa, Italy.
出版信息
Antimicrob Agents Chemother. 2006 Feb;50(2):806-9. doi: 10.1128/AAC.50.2.806-809.2006.
Abstract
The antimicrobial activity of human beta-defensin 3 (hBD-3) against multidrug-resistant clinical isolates of Staphylococcus aureus, Enterococcus faecium, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, and Acinetobacter baumannii was evaluated. A fast bactericidal effect (within 20 min) against all bacterial strains tested was observed. The presence of 20% human serum abolished the bactericidal activity of hBD-3 against gram-negative strains and reduced the activity of the peptide against gram-positive strains.
摘要
评估了人β-防御素3（hBD-3）对金黄色葡萄球菌、粪肠球菌、铜绿假单胞菌、嗜麦芽窄食单胞菌和鲍曼不动杆菌的多重耐药临床分离株的抗菌活性。观察到对所有测试细菌菌株都有快速杀菌作用（20分钟内）。20%人血清的存在消除了hBD-3对革兰氏阴性菌株的杀菌活性，并降低了该肽对革兰氏阳性菌株的活性。
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