Bennett A L, Chao C C, Hu S, Buchwald D, Fagioli L R, Schur P H, Peterson P K, Komaroff A L
Chronic Fatigue Syndrome Cooperative Research Center, Brigham and Women's Hospital, Boston, Massachusetts, USA.
J Clin Immunol. 1997 Mar;17(2):160-6. doi: 10.1023/a:1027330616073.
The level of bioactive transforming growth factor-beta (TGF-beta) was measured in serum from patients with chronic fatigue syndrome (CFS), healthy control subjects, and patients with major depression, systemic lupus erythematosis (SLE), and multiple sclerosis (MS) of both the relapsing/remitting (R/R) and the chronic progressive (CP) types. Patients with CFS had significantly higher levels of bioactive TGF-beta levels compared to the healthy control major depression, SLE, R/R MS, and CP MS groups (P < 0.01). Additionally, no significant differences were found between the healthy control subjects and any of the disease comparison groups. The current finding that TGF-beta is significantly elevated among patients with CFS supports the findings of two previous studies examining smaller numbers of CFS patients. In conclusion, TGF-beta levels were significantly higher in CFS patients compared to patients with various diseases known to be associated with immunologic abnormalities and/or pathologic fatigue. These findings raise interesting questions about the possible role of TGF-beta in the pathogenesis of CFS.
在慢性疲劳综合征（CFS）患者、健康对照者、重度抑郁症患者、系统性红斑狼疮（SLE）患者以及复发/缓解型（R/R）和慢性进展型（CP）多发性硬化（MS）患者的血清中，检测了生物活性转化生长因子-β（TGF-β）的水平。与健康对照、重度抑郁症、SLE、R/R型MS和CP型MS组相比，CFS患者的生物活性TGF-β水平显著更高（P<0.01）。此外，在健康对照者与任何疾病比较组之间未发现显著差异。目前关于CFS患者中TGF-β显著升高的发现支持了之前两项研究的结果，这两项研究检测的CFS患者数量较少。总之，与已知与免疫异常和/或病理性疲劳相关的各种疾病患者相比，CFS患者的TGF-β水平显著更高。这些发现引发了关于TGF-β在CFS发病机制中可能作用的有趣问题。
