Zulet M A, Marti A, Parra M D, Martínez J A
Departamento de Fisiología y Nutrición, Facultad de Farmacia, Universidad de Navarra, Pamplona, Spain.
J Physiol Biochem. 2005 Sep;61(3):483-94. doi: 10.1007/BF03168454.
Data from a number of studies and trials have shown that different conjugated linoleic acids (CLA's) may produce beneficial effects on cancer, atherosclerosis, hypertension, diabetes and changes in body composition. Despite the increasing knowledge about CLA's implications on health, the mechanism of action of these fatty acids is not completely understood. Moreover, human studies indicate that some of these beneficial effects are considerably less evident than anticipated from mice studies, while the efficacy and safety of dietary supplements containing CLA have been questioned in some intervention trials. Recently, it has been suggested that the anti-carcinogenic and anti-atherosclerosis effects of CLA's stem from its anti-inflammatory properties. Because inflammatory responses are associated with the pathophysiology of many diseases, including obesity and the metabolic syndrome, the investigation in this area is of growing interest in recent years.
多项研究和试验的数据表明，不同的共轭亚油酸（CLA）可能对癌症、动脉粥样硬化、高血压、糖尿病以及身体成分变化产生有益影响。尽管人们对CLA对健康的影响了解越来越多，但这些脂肪酸的作用机制尚未完全明确。此外，人体研究表明，其中一些有益效果远不如小鼠研究预期的那么明显，而在一些干预试验中，含CLA的膳食补充剂的功效和安全性也受到了质疑。最近，有人提出CLA的抗癌和抗动脉粥样硬化作用源于其抗炎特性。由于炎症反应与包括肥胖和代谢综合征在内的许多疾病的病理生理学相关，近年来该领域的研究越来越受到关注。
