Newman B H, Satz S L, Janowicz N M, Siegfried B A
American Red Cross Blood Services, Southeastern Michigan Region, Detroit, Michigan 48201, USA.
Transfusion. 2006 Feb;46(2):284-8. doi: 10.1111/j.1537-2995.2006.00713.x.
The high incidence of donor reactions in first-time, 17-year-old Caucasian whole-blood donors makes this group ideal for the study of donor reactions.
Donor reaction rates were retrospectively evaluated in 7274 first-time, 17-year-old Caucasian whole-blood donors based on observations recorded at the collection sites. The effect of sex and weight on donor reactions was determined. In addition, a model was developed to estimate how different blood collection volumes would affect donor reaction rates.
The donor reaction rate was 12.0 percent (870/7274). Female donors overall had a higher donor reaction rate than male donors (16.7% vs. 7.3%) and also had a higher donor reaction rate than male donors at each 20-lb weight interval in the range from 110 to 189 lb. A model suggested that a change in the blood-unit volume from 450 to 500 mL would increase donor reaction rates by 18 percent in either female or male donors, whereas a reduction in the blood-unit volume from 500 to 400 mL would decrease donor reaction rates by 29 and 27 percent in female and male donors, respectively.
First-time, 17-year-old Caucasian female donors had a higher donor reaction rate than male donors overall and at equivalent donor weights. In the range of present US blood-unit volumes, a change in collection of as little as 50 mL could have a significant impact on blood donor reaction rates in high-school students.
首次献血的17岁白种人全血捐献者中供者反应的高发生率使得该群体成为研究供者反应的理想对象。
基于采血点记录的观察结果，对7274名首次献血的17岁白种人全血捐献者的供者反应率进行回顾性评估。确定性别和体重对供者反应的影响。此外，建立了一个模型来估计不同采血量如何影响供者反应率。
供者反应率为12.0%（870/7274）。总体而言，女性供者的供者反应率高于男性供者（16.7%对7.3%），并且在110至189磅的每20磅体重区间内，女性供者的供者反应率也高于男性供者。一个模型表明，血液单位体积从450毫升变为500毫升，女性或男性供者的供者反应率将增加18%，而血液单位体积从500毫升减少至400毫升，女性和男性供者的供者反应率将分别降低29%和27%。
首次献血的17岁白种人女性供者总体上以及在相同供者体重时的供者反应率高于男性供者。在美国目前的血液单位体积范围内，仅50毫升的采血量变化就可能对高中生献血者的反应率产生显著影响。
