Makishima Hideki, Ito Toshiro, Kodama Ryo, Asano Naoko, Nakazawa Hideyuki, Hirabayashi Kazuko, Nakamura Shigeo, Ota Masao, Akamatsu Taiji, Kiyosawa Kendo, Ishida Fumihiro
The Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Int J Hematol. 2006 Jan;83(1):63-5. doi: 10.1532/IJH97.05131.
Intestinal non-Hodgkin's lymphoma (NHL), especially the T-cell type, is well known to be associated with celiac disease (CD), an enteropathic disorder with a propensity for certain racial and genetic backgrounds. CD is typically characterized by gastrointestinal (GI) symptoms, anti-transglutaminase antibodies in the sera, and microscopical findings of the intestinal mucosa, which resolve with a gluten-free diet (GFD). In Asian populations, including the Japanese, CD and the associated NHL have been supposed to be quite rare, and studies concerning the frequency of CD or its relationship with NHL are scarce. We describe a Japanese middle-aged man with intestinal diffuse large B-cell lymphoma associated with CD. Following multi-combined chemotherapy, the patient's lymphoma has been in a state of complete response, and his GI symptoms have improved with a GFD. This case suggests that the possibility of CD and its association with intestinal NHL should be kept in mind, even in Asian populations.
肠道非霍奇金淋巴瘤（NHL），尤其是T细胞型，众所周知与乳糜泻（CD）相关，CD是一种具有特定种族和遗传背景倾向的肠病性疾病。CD的典型特征是胃肠道（GI）症状、血清中的抗转谷氨酰胺酶抗体以及肠道黏膜的显微镜检查结果，这些症状通过无麸质饮食（GFD）得以缓解。在包括日本人在内的亚洲人群中，CD及相关的NHL一直被认为相当罕见，关于CD的发病率或其与NHL关系的研究也很少。我们描述了一名患有与CD相关的肠道弥漫性大B细胞淋巴瘤的日本中年男子。经过多药联合化疗后，患者的淋巴瘤处于完全缓解状态，其胃肠道症状通过GFD得到了改善。该病例表明，即使在亚洲人群中，也应牢记CD及其与肠道NHL关联的可能性。
