Pandolfi A, Manganiello F
Dipartimento di Ingegneria Strutturale, Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy.
Biomech Model Mechanobiol. 2006 Nov;5(4):237-46. doi: 10.1007/s10237-005-0014-x. Epub 2006 Jan 28.
Abstract The human cornea (the external lens of the eye) has the macroscopic structure of a thin shell, originated by the organization of collagen lamellae parallel to the middle surface of the shell. The lamellae, composed of bundles of collagen fibrils, are responsible for the experimentally observed anisotropy of the cornea. Anomalies in the fibril structure may explain the changes in the mechanical behavior of the tissue observed in pathologies such as keratoconus. We employ a fiber-matrix constitutive model and propose a numerical model for the human cornea that is able to account for its mechanical behavior in healthy conditions or in the presence of keratoconus under increasing values of the intraocular pressure. The ability of our model to reproduce the behavior of the human cornea opens a promising perspective for the numerical simulation of refractive surgery.
摘要 人角膜（眼睛的外部晶状体）具有薄壳的宏观结构，由平行于壳中间表面的胶原薄片组织形成。这些薄片由胶原纤维束组成，是角膜实验观察到的各向异性的原因。纤维结构异常可能解释在圆锥角膜等病理情况下观察到的组织力学行为变化。我们采用纤维-基质本构模型，提出了一个人角膜的数值模型，该模型能够解释其在健康状态下或存在圆锥角膜且眼内压不断升高时的力学行为。我们的模型再现人角膜行为的能力为屈光手术的数值模拟开辟了一个有前景的前景。
