Sims Paul F G, Hyde John E
University of Manchester, Faculty of Life Sciences, Jackson's Mill, PO Box 88, Manchester, M60 1QD, UK.
Expert Rev Proteomics. 2006 Feb;3(1):87-95. doi: 10.1586/14789450.3.1.87.
The lethal species of malaria parasite, Plasmodium falciparum, continues to exact a huge toll of mortality and morbidity, particularly in sub-Saharan Africa. Completion of the genome sequence of this organism and advances in proteomics and mass spectrometry have opened up unprecedented opportunities for understanding the complex biology of this parasite and how it responds to drug challenge and other interventions. This review describes recent progress that has been made in applying proteomics technology to this important pathogen and provides a look forward to likely future developments.
致死性疟原虫物种——恶性疟原虫，持续造成巨大的死亡和发病负担，尤其是在撒哈拉以南非洲地区。该生物体基因组序列的完成以及蛋白质组学和质谱技术的进展，为理解这种寄生虫的复杂生物学特性及其对药物挑战和其他干预措施的反应开辟了前所未有的机遇。本综述描述了在将蛋白质组学技术应用于这一重要病原体方面取得的最新进展，并展望了未来可能的发展。
