Schwarz Benjamin A, Bhandoola Avinash
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6082, USA.
Immunol Rev. 2006 Feb;209:47-57. doi: 10.1111/j.0105-2896.2006.00350.x.
T-cell development in the thymus requires periodic importation of hematopoietic progenitors from the bone marrow. Such thymus settling progenitors arise from hematopoietic stem cells (HSCs) that are retained in a specific bone marrow microenvironmental niche. Vacation of this niche is required for HSC proliferation and differentiation into downstream progenitors. In order to reach the thymus, progenitors must then be mobilized from bone marrow to blood. Finally, progenitors in blood must settle in the thymus. Here we review signals and molecular interactions that are likely to play a role in trafficking from the bone marrow to the thymus, focusing on how these interactions may regulate which progenitors physiologically contribute to thymopoiesis.
胸腺中的T细胞发育需要定期从骨髓中导入造血祖细胞。这种进入胸腺的祖细胞源自保留在特定骨髓微环境龛位中的造血干细胞（HSC）。造血干细胞增殖并分化为下游祖细胞需要离开这个龛位。为了到达胸腺，祖细胞必须从骨髓动员到血液中。最后，血液中的祖细胞必须在胸腺中定居。在这里，我们综述了可能在从骨髓到胸腺的运输过程中发挥作用的信号和分子相互作用，重点关注这些相互作用如何调节哪些祖细胞在生理上对胸腺生成有贡献。
