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基库尤人(肯尼亚中部)抗疟民族植物疗法药物的多样性与应用

Diversity and utilization of antimalarial ethnophytotherapeutic remedies among the Kikuyus (Central Kenya).

作者信息

Njoroge Grace N, Bussmann Rainer W

机构信息

Jomo Kenyatta University of Agriculture Science and Technology, Botany Department, P.O. Box 62000, Nairobi, Kenya.

出版信息

J Ethnobiol Ethnomed. 2006 Feb 1;2:8. doi: 10.1186/1746-4269-2-8.

Abstract

Plants in Kenya are becoming increasingly important as sources of traditional medicines. The World Health Organization (WHO) has estimated that malaria kills about 2.7 million people every year, 90% of who are from Africa. Malaria continues to be a national concern in Kenya as it plays a major role in the high mortality rates being experienced currently. The use and mis-use of chloroquine to prevent and treat falciparium malaria has led to widespread appearance of chloroquine resistant parasites in Kenya and other tropical countries. These factors and the rising costs of non-chloroquine drugs have made the local people to turn to traditional remedies for management of this menace. This paper examines the current utilization of traditional plant medicines in managing malaria menace in Central Kenya. The results show both indigenous and introduced species are in use indicating traditional medicinal practices in this region are dynamic. In total 58 species in 54 genera and 33 families were identified. The family Rubiaceae was found to have the highest number of reported species. Use of the various taxa is compared between five districts within Central Province of Kenya. The commonest species in this pharmacopoeia are: Caesalpinia volkensii Harms, Strychnos henningsii Gilg, Ajuga remota Benth., Warbugia ugandensis Sprague and Olea europaea L. The first three species are used in all the five districts while the others are restricted in some of the districts. In 74% of the anti-malarial plant species reported in this study, the remedies are obtained in destructive manner and may need conservation measures to ensure sustainable utilization. The results of this study become a basis for selecting plants for further pharmacological and phytochemical studies in developing new and locally relevant anti-malarial agents.

摘要

肯尼亚的植物作为传统药物来源正变得越来越重要。世界卫生组织(WHO)估计,疟疾每年导致约270万人死亡,其中90%来自非洲。疟疾在肯尼亚仍然是一个全国性的关注点,因为它在当前高死亡率中起着主要作用。氯喹用于预防和治疗恶性疟疾的不当使用,导致肯尼亚和其他热带国家出现了对氯喹耐药的寄生虫。这些因素以及非氯喹药物成本的上升,使得当地民众转向传统疗法来应对这一威胁。本文研究了肯尼亚中部地区传统植物药在应对疟疾威胁方面的当前使用情况。结果表明,本地物种和引进物种都在被使用,这表明该地区的传统医学实践是动态的。总共鉴定出54属33科的58个物种。发现茜草科的报道物种数量最多。对肯尼亚中部省五个地区之间各种分类群的使用情况进行了比较。这本药典中最常见的物种有:沃氏云实属的沃氏云实、亨氏马钱、远距筋骨草、乌干达桂皮和油橄榄。前三个物种在所有五个地区都有使用,而其他物种在一些地区受到限制。在本研究报告的抗疟植物物种中,74%的药物是以破坏性方式获取的,可能需要采取保护措施以确保可持续利用。本研究结果为选择植物进行进一步的药理学和植物化学研究以开发新的、适合当地的抗疟药物提供了依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80df/1397805/3c4df23d7c65/1746-4269-2-8-2.jpg

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