马拉维药用植物粗提物中的抗疟活性。

Antimalarial activity in crude extracts of Malawian medicinal plants.

作者信息

Connelly M P, Fabiano E, Patel I H, Kinyanjui S M, Mberu E K, Watkins W M

机构信息

Chemistry Department, Chancellor College, University of Malawi, Zomba, Malawi.

出版信息

Ann Trop Med Parasitol. 1996 Dec;90(6):597-602. doi: 10.1080/00034983.1996.11813089.

DOI:10.1080/00034983.1996.11813089

PMID:9039271

Abstract

Aqueous and organic fractions from Cassia abbreviata, Senna petersiana (both Caesalpiniaceae) and Azanza garckeana (Malvaceae) were tested for in-vitro antimalarial activity against the multi-drug-resistant, Vietnam-Smith strain of Plasmodium falciparum; VI/S. Both roots and leaves from these Malawian medicinal plants were investigated. High activity, with a median inhibitory concentration < 3 micrograms/ml, was seen in the organic fractions of C. abbreviata and S. petersiana, the two species most commonly cited by traditional healers in an ethnobotanical investigation of Malawian antimalarials. Extracts of A. garckeana showed weaker activity. Biologically active compounds have thus been detected within species of the family Caesalpiniaceae. Ethnobotanical investigation appears to be useful in identifying plants with antimalarial activity.

摘要

对来自短叶决明、彼得氏番泻（均为豆科）和加氏阿赞木（锦葵科）的水相和有机相提取物进行了体外抗疟活性测试，以检测其对多重耐药的越南 - 史密斯恶性疟原虫株（VI/S）的作用。对这些马拉维药用植物的根和叶均进行了研究。在短叶决明和彼得氏番泻的有机相中观察到高活性，其半数抑制浓度<3微克/毫升，这两个物种在马拉维抗疟植物的民族植物学调查中是传统治疗师最常提及的。加氏阿赞木的提取物活性较弱。因此，在豆科植物中检测到了生物活性化合物。民族植物学调查似乎有助于识别具有抗疟活性的植物。