Sato R, Helzlsouer K J, Comstock G W, Hoffman S C, Norkus E P, Fried L P
Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.
J Nutr Health Aging. 2006 Jan-Feb;10(1):37-44.
Previous studies have suggested that vitamin C status may be associated with cognitive function in community-dwelling populations. However, this has not been consistent across all studies due to methodological differences. This cross-sectional study assessed the association between vitamin C and cognitive function in 544 community-dwelling older adults aged 65 or older who participated in both the Cardiovascular Health Study (CHS) and the CLUE II study in 1989. Three percent of the subjects had low plasma vitamin C concentrations (< 40 mg/dL) and 15% had low total vitamin C intake (< 60 mg/day). Most participants (96.7 percent) had normal cognitive function. In the unadjusted analyses, the highest fifth of plasma vitamin C concentration was associated with better Digit Symbol Substitution Test (DSST) scores and marginally associated with Mini-Mental State Examination (MMSE) compared to the lowest fifth. Total vitamin C intake, measured by Block's food frequency questionnaire, was generally associated with higher MMSE scores, though it was not significant. Adjusting for numerous factors did not substantially change results. In a stratified analysis by gender, higher plasma concentrations or intake were associated with higher MMSE scores for men but not for women. These mixed results do not provide strong evidence of an association between vitamin C concentrations or intake and cognitive function.
先前的研究表明，在社区居住人群中，维生素C状态可能与认知功能有关。然而，由于方法学上的差异，并非所有研究结果都一致。这项横断面研究评估了1989年参与心血管健康研究（CHS）和CLUE II研究的544名65岁及以上社区居住老年人中维生素C与认知功能之间的关联。3%的受试者血浆维生素C浓度较低（<40mg/dL），15%的受试者总维生素C摄入量较低（<60mg/天）。大多数参与者（96.7%）认知功能正常。在未调整的分析中，与最低五分位数相比，血浆维生素C浓度最高的五分位数与更好的数字符号替换测验（DSST）得分相关，与简易精神状态检查表（MMSE）得分呈微弱相关。通过Block食物频率问卷测量的总维生素C摄入量通常与较高的MMSE得分相关，尽管不显著。调整众多因素后，结果没有实质性变化。在按性别分层的分析中，较高的血浆浓度或摄入量与男性较高的MMSE得分相关，但与女性无关。这些混合结果并未提供有力证据证明维生素C浓度或摄入量与认知功能之间存在关联。
