Johnson R B
Pfizer Central Research, Groton, CT 06340.
Am J Obstet Gynecol. 1991 Jun;164(6 Pt 2):1794-6. doi: 10.1016/0002-9378(91)90562-6.
Chlamydia trachomatis causes an estimated 4 million infections each year in the United States. Sequelae in women include infertility and ectopic pregnancy. Doxycycline, the current standard therapy, must be taken twice daily for at least 7 days. Patient compliance is often poor, leading to recurrent disease. Azithromycin, a new antibiotic of the azalide class, achieves high and sustained intracellular levels and demonstrates excellent in vitro activity against C. trachomatis. Reported herein are the results of three comparative clinical trials, which demonstrate that single-dose oral therapy with azithromycin is as effective as a standard 7-day twice-daily course of doxycycline in the treatment of uncomplicated genital infections caused by C. trachomatis.
在美国，沙眼衣原体每年估计会导致400万例感染。女性的后遗症包括不孕和宫外孕。目前的标准疗法多西环素必须每天服用两次，至少服用7天。患者的依从性往往较差，导致疾病复发。阿奇霉素是一种新型氮杂内酯类抗生素，能在细胞内达到高且持续的浓度，并在体外对沙眼衣原体显示出优异的活性。本文报告了三项比较临床试验的结果，这些试验表明，单剂量口服阿奇霉素治疗沙眼衣原体引起的单纯性生殖器感染与标准的多西环素每日两次、疗程7天的疗法同样有效。
