Hammerschlag M R, Golden N H, Oh M K, Gelling M, Sturdevant M, Brown P R, Aras Z, Neuhoff S, Dumornay W, Roblin P M
Department of Pediatrics, State University of New York Health Science Center, Brooklyn 11203.
J Pediatr. 1993 Jun;122(6):961-5. doi: 10.1016/s0022-3476(09)90029-4.
We compared a single 1 gm dose of azithromycin with the standard 7-day course of doxycycline for the treatment of uncomplicated chlamydial genital infection in sexually active adolescents. Seventy-three adolescents (65 female) with a cervical or urethral culture positive for Chlamydia trachomatis were enrolled in the study; 46 received azithromycin and 27 received doxycycline. Follow-up evaluations were done 1, 2, and 4 weeks after treatment with azithromycin or initiation of treatment with doxycycline. There were four treatment failures (8.7%) among the patients who received azithromycin and four in the doxycycline-treated group (14.8%); all were female. Six of these girls (three treated with azithromycin and three with doxycycline) gave histories of unprotected intercourse with an untreated partner and were probably reinfected. Almost half the patients were clinically symptom free. The clinical response rate for the remaining patients with symptoms was 97.4% at 4 weeks. Nineteen percent of the azithromycin-treated patients and 33.3% of those treated with doxycycline had mild to moderate drug-related side effects, which were predominantly gastrointestinal. We conclude that treatment with a single oral dose of azithromycin appears to be as safe and efficacious as a 7-day course of doxycycline for the treatment of uncomplicated genital chlamydial infection in adolescents.
我们比较了单剂量1克阿奇霉素与标准的7天疗程强力霉素，用于治疗性活跃青少年的非复杂性衣原体性生殖器感染。73名沙眼衣原体宫颈或尿道培养呈阳性的青少年（65名女性）被纳入该研究；46名接受阿奇霉素治疗，27名接受强力霉素治疗。在阿奇霉素治疗后或强力霉素开始治疗后的1、2和4周进行随访评估。接受阿奇霉素治疗的患者中有4例治疗失败（8.7%），强力霉素治疗组中有4例（14.8%）；均为女性。其中6名女孩（3名接受阿奇霉素治疗，3名接受强力霉素治疗）有与未治疗伴侣进行无保护性交的病史，可能再次感染。几乎一半的患者临床上无症状。其余有症状患者在4周时的临床缓解率为97.4%。接受阿奇霉素治疗的患者中有19%，接受强力霉素治疗的患者中有33.3%有轻度至中度药物相关副作用，主要为胃肠道副作用。我们得出结论，对于青少年非复杂性生殖器衣原体感染的治疗，单剂量口服阿奇霉素似乎与7天疗程的强力霉素一样安全有效。
