Essex M, Cotter S M, Carpenter J L, Hardy W D, Hess P, Jarrett W, Schaller J, Yohn D S
J Natl Cancer Inst. 1975 Mar;54(3):631-5.
Antibody titers to the feline oncornavirusassociated cell membrane antigen (FOCMA) were determined for 447 healthy cats from laboratory colony and household environments. Only 2.7 percent of 221 cats from colony environments were antibody positive as compared to 50.4 percent of 256 cats from household environments. Incidence of FOCMA antibody and geometric mean antibody titer for pet cats from New York City representing single cat apartment habitats were substantially lower than values for unscreened cats from the Boston, Glasgow, and Detroit suburban environments. Geometric mean antibody titer for young adults in the Boston population was significantly higher than titers for kittens or aged cats. This may be due to greater mobility resulting in increased exposure to other cats. In contrast to the high frequency of FOCMA antibody positivity in pet-cat populations, less than 2 percent of the same groups were positive for virus group-specific antigen in peripheral blood leukocytes and platelets. This was interpreted as an indication that many more cats became infected with feline leukemia virus under natural conditions that the number developing persistent virus infection and/or clinical leukemia.
对来自实验室种群和家庭环境的447只健康猫测定了抗猫肿瘤病毒相关细胞膜抗原（FOCMA）的抗体滴度。来自种群环境的221只猫中只有2.7%抗体呈阳性，而来自家庭环境的256只猫中有50.4%抗体呈阳性。代表单猫公寓栖息地的纽约市宠物猫的FOCMA抗体发生率和几何平均抗体滴度显著低于来自波士顿、格拉斯哥和底特律郊区环境的未筛查猫的值。波士顿猫群中年轻成年猫的几何平均抗体滴度显著高于小猫或老年猫。这可能是由于活动能力增强导致接触其他猫的机会增加。与宠物猫群体中FOCMA抗体阳性的高频率相反，同一组中不到2%的猫在外周血白细胞和血小板中病毒组特异性抗原呈阳性。这被解释为表明在自然条件下感染猫白血病病毒的猫比发生持续性病毒感染和/或临床白血病的猫的数量要多得多。
