Piton G, Dupont-Gossart A-C, Weber A, Herbein G, Viennet G, Mantion G, Carbonnel F
Service de gastroentérologie et nutrition, centre hospitalier universitaire, boulevard Fleming, 25000 Besançon, France.
Gastroenterol Clin Biol. 2008 May;32(5 Pt 1):460-4. doi: 10.1016/j.gcb.2007.10.010. Epub 2008 Mar 24.
CMV reactivation is frequently observed in acute flares of ulcerative colitis (UC), particularly those which do not respond to intravenous steroids. Several recent series have suggested that, in most cases, CMV reactivation does not lead to severe complications and resolves spontaneously with the UC flare and discontinuation of immunosuppression. In the present paper, we describe two patients with active UC who developed a severe systemic CMV infection during a treatment with an oral microemulsion form of cyclosporine. This is of concern, particularly in a context of increasing use of immunosuppressive drugs in UC. We propose a prophylactic and curative approach to decrease morbidity related to CMV infection in active UC.
巨细胞病毒（CMV）再激活在溃疡性结肠炎（UC）的急性发作中经常出现，尤其是那些对静脉注射类固醇无反应的发作。最近的一些系列研究表明，在大多数情况下，CMV再激活不会导致严重并发症，并且会随着UC发作的缓解和免疫抑制的停用而自发消退。在本文中，我们描述了两名活动性UC患者，他们在接受口服微乳剂形式的环孢素治疗期间发生了严重的全身性CMV感染。这一点值得关注，尤其是在UC中免疫抑制药物使用增加的背景下。我们提出了一种预防和治疗方法，以降低活动性UC中与CMV感染相关的发病率。
