口蹄疫病毒突变体的适应性改变：病毒准种适应性的测定
Fitness alteration of foot-and-mouth disease virus mutants: measurement of adaptability of viral quasispecies.
作者信息
Martínez M A, Carrillo C, González-Candelas F, Moya A, Domingo E, Sobrino F
机构信息
Departamento de Sanidad Animal, Instituto Nacional de Investigaciones Agrarias, Madrid, Spain.
出版信息
J Virol. 1991 Jul;65(7):3954-7. doi: 10.1128/JVI.65.7.3954-3957.1991.
Abstract
We document the rapid alteration of fitness of two foot-and-mouth disease virus (FMDV) mutants resistant to a neutralizing monoclonal antibody. Both mutants showed a selective disadvantage in BHK-21 cells when passaged in competition with their parental FMDV. Upon repeated replication of the mutants alone, they acquired a selective advantage over the parental FMDV and fixed additional genomic substitutions without reversion of the monoclonal antibody-resistant phenotype. Thus, variants that were previously kept at low frequency in the mutant spectrum of a viral quasispecies rapidly became the master sequence of a new genomic distribution and dominated the viral population.
摘要
我们记录了两种抗中和单克隆抗体的口蹄疫病毒（FMDV）突变体适应性的快速改变。当与它们的亲本FMDV竞争传代时，这两种突变体在BHK - 21细胞中均表现出选择性劣势。在单独对突变体进行反复传代复制后，它们相对于亲本FMDV获得了选择性优势，并固定了额外的基因组替换，而单克隆抗体抗性表型并未回复。因此，先前在病毒准种突变谱中以低频存在的变体迅速成为新基因组分布的主导序列，并在病毒群体中占据主导地位。
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