Piccione F, Giorgi F, Tonin P, Priftis K, Giove S, Silvoni S, Palmas G, Beverina F
IRCCS, S. Camillo Hospital, Alberoni, 70, 30126 Venice, Italy.
Clin Neurophysiol. 2006 Mar;117(3):531-7. doi: 10.1016/j.clinph.2005.07.024. Epub 2006 Feb 2.
This study aimed to describe the use of the P300 event-related potential as a control signal in a brain computer interface (BCI) for healthy and paralysed participants.
The experimental device used the P300 wave to control the movement of an object on a graphical interface. Visual stimuli, consisting of four arrows (up, right, down, left) were randomly presented in peripheral positions on the screen. Participants were instructed to recognize only the arrow indicating a specific direction for an object to move. P300 epochs, synchronized with the stimulus, were analyzed on-line via Independent Component Analysis (ICA) with subsequent feature extraction and classification by using a neural network.
We tested the reliability and the performance of the system in real-time. The system needed a short training period to allow task completion and reached good performance. Nonetheless, severely impaired patients had lower performance than healthy participants.
The proposed system is effective for use with healthy participants, whereas further research is needed before it can be used with locked-in syndrome patients.
The P300-based BCI described can reliably control, in 'real time', the motion of a cursor on a graphical interface, and no time-consuming training is needed in order to test possible applications for motor-impaired patients.
本研究旨在描述将P300事件相关电位用作健康参与者和瘫痪参与者脑机接口（BCI）中的控制信号。
实验装置利用P300波来控制图形界面上物体的移动。由四个箭头（上、右、下、左）组成的视觉刺激随机呈现在屏幕的周边位置。参与者被指示只识别指示物体特定移动方向的箭头。与刺激同步的P300时段通过独立成分分析（ICA）进行在线分析，随后使用神经网络进行特征提取和分类。
我们实时测试了系统的可靠性和性能。该系统需要较短的训练期以完成任务，并达到了良好的性能。尽管如此，严重受损患者的表现低于健康参与者。
所提出的系统对健康参与者有效，而在可用于闭锁综合征患者之前还需要进一步研究。
所描述的基于P300的BCI可以“实时”可靠地控制图形界面上光标的移动，并且无需耗时的训练即可测试对运动受损患者的可能应用。
