Rodgers G M, Fisher J W, George W J
Proc Soc Exp Biol Med. 1975 Feb;148(2):380-2. doi: 10.3181/00379727-148-38543.
Chronic treatment of normal mice with either dibutyryl cyclic AMP or erythropoietin produced elevations in the hematocrit, hemoglobin concentration and red cell mass when compared to these same hematological parameters in untreated mice. Dibutyryl cyclic AMP increased red cell mass by 46% while ESF treatment resulted in a 56% increase in red cell mass. These studies confirm earlier reports of the effects of cyclic AMP in increasing radioactive iron incorporation into red cells and further indicate that this change is associated with an absolute increase renal cyclic AMP concentrations probably stimulate erythropoiesis as a consequence of increased kidney production of erythropoietin.
与未接受治疗的小鼠的相同血液学参数相比，用二丁酰环磷腺苷或促红细胞生成素对正常小鼠进行长期治疗会导致血细胞比容、血红蛋白浓度和红细胞量升高。二丁酰环磷腺苷使红细胞量增加了46%，而促红细胞生成素治疗使红细胞量增加了56%。这些研究证实了早期关于环磷腺苷增加放射性铁掺入红细胞的作用的报道，并进一步表明这种变化与肾脏环磷腺苷浓度的绝对增加有关，可能是由于肾脏促红细胞生成素产生增加而刺激了红细胞生成。
