LaMontagne A D, Radi S, Elder D S, Abramson M J, Sim M
Centre for Health & Society, School of Population Health, University of Melbourne, Melbourne, VIC, Australia.
Occup Environ Med. 2006 May;63(5):359-64. doi: 10.1136/oem.2005.025221. Epub 2006 Feb 9.
Eight primary prevention intervention studies on natural rubber latex (NRL) published since 1990 were identified and reviewed. This is the largest evidence base of primary prevention studies for any occupational asthmagen.
Review of this small and largely observational evidence base supports the following evidence statement: Substitution of powdered latex gloves with low protein powder-free NRL gloves or latex-free gloves greatly reduces NRL aeroallergens, NRL sensitisation, and NRL-asthma in healthcare workers. Evidence in support of this statement is ranked SIGN level 2+, referring to well conducted case-control or cohort studies with a low risk of confounding, bias, or chance and a moderate probability that the relationship is causal.
Substitution of powdered latex gloves with low protein powder-free NRL gloves or latex-free gloves promises benefits to both workers' health and cost and human resource savings for employers. This message should be broadly disseminated beyond the hospital sector to include other healthcare settings (such as aged care facilities) as well as food service and other industries where latex gloves might be used.
识别并回顾了自1990年以来发表的八项关于天然橡胶乳胶（NRL）的一级预防干预研究。这是针对任何职业性变应原的一级预防研究的最大证据库。
对这个规模较小且大多为观察性的证据库进行回顾后，支持以下证据陈述：用低蛋白无粉NRL手套或无乳胶手套替代粉末状乳胶手套，可大大降低医护人员接触NRL空气变应原、NRL致敏和NRL诱发哮喘的几率。支持该陈述的证据等级为SIGN 2+级，指的是进行良好的病例对照或队列研究，混杂、偏倚或机遇风险较低，且该关系具有因果性的可能性中等。
用低蛋白无粉NRL手套或无乳胶手套替代粉末状乳胶手套有望对工人健康有益，同时为雇主节省成本和人力资源。这一信息应广泛传播至医院部门以外，涵盖其他医疗环境（如老年护理机构）以及可能使用乳胶手套的食品服务和其他行业。
