Feldkamp Udo, Niemeyer Christof M
Fachbereich Chemie, Biologisch-Chemische Mikrostrukturtechnik, Universität Dortmund, Germany.
Angew Chem Int Ed Engl. 2006 Mar 13;45(12):1856-76. doi: 10.1002/anie.200502358.
DNA has many physical and chemical properties that make it a powerful material for molecular constructions at the nanometer length scale. In particular, its ability to form duplexes and other secondary structures through predictable nucleotide-sequence-directed hybridization allows for the design of programmable structural motifs which can self-assemble to form large supramolecular arrays, scaffolds, and even mechanical and logical nanodevices. Despite the large variety of structural motifs used as building blocks in the programmed assembly of supramolecular DNA nanoarchitectures, the various modules share underlying principles in terms of the design of their hierarchical configuration and the implemented nucleotide sequences. This Review is intended to provide an overview of this fascinating and rapidly growing field of research from the structural design point of view.
DNA具有许多物理和化学特性，使其成为纳米长度尺度分子构建的强大材料。特别是，它能够通过可预测的核苷酸序列导向杂交形成双链体和其他二级结构，这使得可编程结构基序的设计成为可能，这些基序可以自组装形成大型超分子阵列、支架，甚至机械和逻辑纳米器件。尽管在超分子DNA纳米结构的程序化组装中用作构建块的结构基序种类繁多，但各种模块在其层次结构设计和所实施的核苷酸序列方面具有共同的基本原理。本综述旨在从结构设计的角度对这一迷人且快速发展的研究领域进行概述。
