Sichieri R, Everhart J E, Roth H
Epidemiology and Data Systems Program, NIH/NIDDK, Bethesda, MD 20892.
Am J Public Health. 1991 Jul;81(7):880-4. doi: 10.2105/ajph.81.7.880.
Dietary risk factors for the development of gallstones have not been clearly established. We analyzed data from a population-based prospective study to determine dietary risk factors for hospitalization with gallstone disease.
We evaluated the role of dietary constituents, fasting, and dieting on subsequent hospitalization with gallstone disease among 4,730 women, ages 25 to 74 years, who participated in the first follow-up of the first National Health and Nutrition Examination Survey. Baseline dietary variables were established through a 24-hour dietary recall and a medical history. Proportional hazards models were used to calculate the effects of dietary variables while controlling for baseline risk factors.
After an average of 10 years follow-up, gallstone disease was confirmed by hospital records among 216 women who denied gallstone disease at the baseline examination. The hazard rate of hospitalization with gallstone disease increased with increasing overnight fasting period and with dieting. Intake of fiber showed a small protective effect. The effect of energy intake was significant only among women younger than age 50 years at baseline. Results were not affected by adjustment for known risk factors for gallstone disease or other dietary factors.
A long overnight fasting period, dieting, and low fiber intake may increase the risk of hospitalization with gallstone disease.
胆结石形成的饮食风险因素尚未明确确立。我们分析了一项基于人群的前瞻性研究的数据，以确定胆结石疾病住院治疗的饮食风险因素。
我们评估了饮食成分、禁食和节食对4730名年龄在25至74岁之间参与首次全国健康与营养检查调查首次随访的女性随后因胆结石疾病住院的作用。通过24小时饮食回顾和病史确定基线饮食变量。比例风险模型用于计算饮食变量的影响，同时控制基线风险因素。
平均随访10年后，医院记录证实216名在基线检查时否认患有胆结石疾病的女性患有胆结石疾病。胆结石疾病住院的风险率随着夜间禁食时间的延长和节食而增加。纤维摄入显示出较小的保护作用。能量摄入的影响仅在基线时年龄小于50岁的女性中显著。结果不受胆结石疾病已知风险因素或其他饮食因素调整的影响。
长时间的夜间禁食、节食和低纤维摄入可能会增加因胆结石疾病住院的风险。
