Huang Angie W, Wei Min, Caputo Sara, Wilson Melissa L, Antoun Joseph, Hsu William C
L-Nutra, Inc., Plano, TX 75024, USA.
Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Nutrients. 2021 Apr 30;13(5):1523. doi: 10.3390/nu13051523.
There has been increasing interest in time-restricted eating to attain intermittent fasting's metabolic benefits. However, a more extended daily fast poses many challenges. This study was designed to evaluate the effects of a 200-calorie fasting-mimicking diet (FMD) energy bar formulated to prolong ketogenesis and mitigate fasting-associated side effects. A randomized, controlled study was conducted comparing the impact of consuming an FMD bar vs. continued water fast, after a 15-h overnight fast. Subjects in the FMD group showed a 3-h postprandial beta-hydroxybutyrate (BHB) level and 4-h postprandial BHB area under the curve () that were non-inferior to those who continued with the water fast ( = 0.891 and = 0.377, respectively). The postprandial glucose in the FMD group was non-inferior to that in the water fast group ( = 0.899). A breakfast group served as a control, which confirmed that the instrument used in home glucose and ketone monitoring functioned as expected. The results indicate that FMD bar consumption does not interfere with the physiological ketogenesis associated with overnight fasting and could be used to facilitate the practice of time-restricted eating or intermittent fasting.
为获得间歇性禁食的代谢益处，人们对限时进食的兴趣与日俱增。然而，更长时间的每日禁食带来了诸多挑战。本研究旨在评估一种200卡路里的模拟禁食饮食（FMD）能量棒的效果，该能量棒旨在延长生酮作用并减轻与禁食相关的副作用。在进行15小时夜间禁食后，开展了一项随机对照研究，比较食用FMD能量棒与持续禁食水的影响。FMD组受试者餐后3小时的β-羟基丁酸（BHB）水平以及餐后4小时的BHB曲线下面积（）不劣于持续禁食水的受试者（分别为 = 0.891和 = 0.377）。FMD组的餐后血糖不劣于禁食水组（ = 0.899）。一个早餐组作为对照，证实了家庭血糖和酮体监测所用仪器运行正常。结果表明，食用FMD能量棒不会干扰与夜间禁食相关的生理性生酮作用，可用于促进限时进食或间歇性禁食的实践。
