Milerová Jana, Cerovská Jarmila, Zamrazil Václav, Bílek Radovan, Lapcík Oldrich, Hampl Richard
Institute of Endocrinology, Praha, Czech Republic.
Clin Chem Lab Med. 2006;44(2):171-4. doi: 10.1515/CCLM.2006.031.
Thyroid hormones and thyroid autoantibodies, along with serum concentrations of two phytoestrogens of the isoflavone series, daidzein and genistein, were measured in 268 children without overt thyroid diseases, screened for iodine deficiency in one region of the Czech Republic. Since both phytoestrogens have been reported to inhibit thyroid hormone biosynthesis and in high concentrations to exert goitrogenic effects, we investigated whether their presence in the circulation could influence thyroid hormone function in a population where soy consumption is not common. Correlation analysis revealed a significant positive association of genistein with thyroglobulin autoantibodies and a negative correlation with thyroid volume. Multiple regression analysis of the relationships between actual phytoestrogen levels and measured thyroid parameters revealed only a weak but significant association between genistein and thyroid variables. Higher levels of free thyroxine were found in a subgroup of 36 children who ate soy food in the previous 24 h. In conclusion, only modest association was found between actual phytoestrogen levels and parameters of thyroid function. On the other hand, even small differences in soy phytoestrogen intake may influence thyroid function, which could be important when iodine intake is insufficient.
在捷克共和国一个地区对268名无明显甲状腺疾病的儿童进行了甲状腺激素、甲状腺自身抗体以及两种异黄酮系列植物雌激素（大豆苷元和染料木黄酮）血清浓度的检测，这些儿童均经过碘缺乏筛查。由于据报道这两种植物雌激素均会抑制甲状腺激素的生物合成，且高浓度时会产生致甲状腺肿作用，我们调查了在大豆消费并不普遍的人群中，其在血液循环中的存在是否会影响甲状腺激素功能。相关性分析显示，染料木黄酮与甲状腺球蛋白自身抗体呈显著正相关，与甲状腺体积呈负相关。对实际植物雌激素水平与所测甲状腺参数之间关系进行的多元回归分析表明，大豆苷元与甲状腺变量之间仅存在微弱但显著的关联。在之前24小时内食用过大豆食品的36名儿童亚组中，发现游离甲状腺素水平较高。总之，实际植物雌激素水平与甲状腺功能参数之间仅存在适度关联。另一方面，即使大豆植物雌激素摄入量存在微小差异也可能影响甲状腺功能，在碘摄入量不足时这可能很重要。
