单纯疱疹病毒和水痘带状疱疹病毒，这些从不离开的住客。
Herpes simplex virus and varicella zoster virus, the house guests who never leave.
作者信息
Kinchington Paul R, Leger Anthony J St, Guedon Jean-Marc G, Hendricks Robert L
机构信息
Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
出版信息
Herpesviridae. 2012 Jun 12;3(1):5. doi: 10.1186/2042-4280-3-5.
Abstract
Human alphaherpesviruses including herpes simplex viruses (HSV-1, HSV-2) and varicella zoster virus (VZV) establish persistent latent infection in sensory neurons for the life of the host. All three viruses have the potential to reactivate causing recurrent disease. Regardless of the homology between the different virus strains, the three viruses are characterized by varying pathologies. This review will highlight the differences in infection pattern, immune response, and pathogenesis associated with HSV-1 and VZV.
摘要
包括单纯疱疹病毒（HSV-1、HSV-2）和水痘带状疱疹病毒（VZV）在内的人类α疱疹病毒会在宿主的感觉神经元中建立持续的潜伏感染。这三种病毒都有可能重新激活，引发复发性疾病。尽管不同病毒株之间存在同源性，但这三种病毒具有不同的病理学特征。本综述将重点介绍与HSV-1和VZV相关的感染模式、免疫反应和发病机制的差异。
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