Moon Nam Ju, Lee Hyeon Il, Kim Jae Chan
Department of Ophthalmology, College of Medicine, Chung-Ang University, Seoul, Korea.
J Korean Med Sci. 2006 Feb;21(1):131-5. doi: 10.3346/jkms.2006.21.1.131.
To determine if the involuntary contractions of eyelids may have any effects on the development of corneal astigmatism, we performed this prospective study which includes 19 patients with either essential blepharospasm or hemifacial spasm. In hemifacial spasm, the degree of corneal astigmatism was evaluated between two eyes. Then the topographic changes were checked using vector analysis technique before and after passively opening the eyelids. They were also measured before and at 1 and 6 months after the injection of Botulinum toxin. Resultantly, 20 eyes had the with-the-rule (group1) and 9 eyes against-the-rule (group2) astigmatism. In hemifacial spasm, significantly more astigmatism was found at spastic eyes. The corneal topographic changes after passively opening the eyelids showed 10 eyes with the astigmatic shift to the with-the-rule, while the remaining 19 to the against the- rule. At 1 month after injection of Botulinum toxin, group 1 showed reduced average corneal astigmatism, whereas group 2 showed increased astigmatism. The astigmatic change vector showed significantly more against-the-rule. In the contrary, 6 months after treatment, corneal astigmatism again increased in group 1 and decreased in group 2. So they took on the appearance of pretreatment astigmatic status eventually. Conclusively eyelids may play an important role in corneal curvature.
为了确定眼睑的不自主收缩是否会对角膜散光的发展产生任何影响，我们进行了这项前瞻性研究，该研究纳入了19例患有原发性眼睑痉挛或半面痉挛的患者。在半面痉挛患者中，评估双眼之间的角膜散光程度。然后在被动睁眼前后使用矢量分析技术检查地形图变化。在注射肉毒杆菌毒素前、注射后1个月和6个月也进行了测量。结果，20只眼为顺规散光（第1组），9只眼为逆规散光（第2组）。在半面痉挛患者中，痉挛眼的散光明显更多。被动睁眼后的角膜地形图变化显示，有散光轴向顺规方向偏移的有10只眼，其余19只眼的散光轴向逆规方向偏移。注射肉毒杆菌毒素1个月后，第1组平均角膜散光降低，而第2组散光增加。散光变化矢量显示逆规方向的变化明显更多。相反，治疗6个月后，第1组角膜散光再次增加，第2组角膜散光减少。最终它们呈现出治疗前散光状态的表现。结论是眼睑可能在角膜曲率中起重要作用。
