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Influence of experimental alcoholism on the repair process of bone defects filled with beta-tricalcium phosphate.实验性酒精中毒对β-磷酸三钙填充骨缺损修复过程的影响。
Drug Alcohol Depend. 2019 Apr 1;197:315-325. doi: 10.1016/j.drugalcdep.2018.12.031. Epub 2019 Feb 16.
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Coacervation of α-elastin studied by ultrafast nonlinear infrared spectroscopy.用超快非线性红外光谱研究α-弹性蛋白的凝聚。
Phys Chem Chem Phys. 2016 Oct 12;18(40):27981-27990. doi: 10.1039/c6cp04049g.
4
Composition of elastin like polypeptide-collagen composite scaffold influences in vitro osteogenic activity of human adipose derived stem cells.弹性蛋白样多肽-胶原蛋白复合支架的组成影响人脂肪来源干细胞的体外成骨活性。
Dent Mater. 2016 Oct;32(10):1270-1280. doi: 10.1016/j.dental.2016.07.009. Epub 2016 Aug 11.
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Effects of low-level laser therapy on autogenous bone graft stabilized with a new heterologous fibrin sealant.低水平激光治疗对新型异种纤维蛋白胶稳定的自体骨移植物的影响。
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Feasibility study of collagen membranes derived from bovine pericardium and intestinal serosa for the repair of cranial defects in ovariectomised rats.牛心包和肠浆膜来源的胶原膜修复去卵巢大鼠颅骨缺损的可行性研究
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使用弹性蛋白基质联合骨形态发生蛋白修复颅骨缺损的适用性。

Suitability of the use of an elastin matrix combined with bone morphogenetic protein for the repair of cranial defects.

作者信息

de Moraes Renato, de Guzzi Plepis Ana Maria, da Conceição Amaro Martins Virginia, Duarte Marco Antonio Hungaro, Alcalde Murilo Priori, Buchaim Rogerio Leone, Pomini Karina Torres, Machado Eduardo Gomes, de Azevedo E Sousa Munhoz Marcelo, Cunha Fernando Bento, Calegari Amanda Regina Alves, Iatecola Amilton, Silva Samantha Ketelyn, da Cunha Marcelo Rodrigues

机构信息

Department of Morphology and Pathology, Medical College of Jundiai São Paulo, Jundiaí 13202-550, SP, Brazil.

Interunit Postgraduate Program in Bioengineering (EESC/FMRP/IQSC), University São Paulo, USP São Carlos 3566-590, SP, Brazil.

出版信息

Am J Transl Res. 2019 Aug 15;11(8):5261-5271. eCollection 2019.

PMID:31497239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6731398/
Abstract

The use of biomaterials in medical and dental areas has become increasingly important due to the need to restore areas with bone loss or defects. This study analyzed the use of a new elastin polymer matrix combined with Bone Morphogenetic Protein for the repair of cranial defects in rats. Thirty rats were divided into five groups: control (C) defect without graft, E24 (defect filled with elastin matrix submitted to alkaline hydrolysis at 50°C for 24 h), E24/BMP (defect filled with elastin matrix treated at 50°C for 24 h plus BMP), E96 (defect filled with elastin matrix treated at 37°C for 96 h) and E96/BMP (defect filled with elastin matrix treated at 37°C for 96 h plus BMP). The animals were killed after 6 weeks. In the histological and microtomographic analysis, all groups showed bone growth from the defect margins remaining in this region without a marked inflammatory process, but in the E96/BMP group the lamellae were thicker and the collagen fibers more organized. Histometrically, the same group presented higher percentage of new formation (43.25 ± 3.72) in relation to the other groups. It was concluded that the support and delivery system formed by the elastin matrix associated with BMPs had a positive effect on the bone repair process.

摘要

由于需要修复骨质流失或缺损的区域，生物材料在医学和牙科领域的应用变得越来越重要。本研究分析了一种新型弹性蛋白聚合物基质与骨形态发生蛋白联合用于修复大鼠颅骨缺损的情况。将30只大鼠分为五组：对照组（C），有缺损但未移植；E24组（缺损填充经50°C碱性水解24小时的弹性蛋白基质）；E24/BMP组（缺损填充经50°C处理24小时的弹性蛋白基质加骨形态发生蛋白）；E96组（缺损填充经37°C处理96小时的弹性蛋白基质）；E96/BMP组（缺损填充经37°C处理96小时的弹性蛋白基质加骨形态发生蛋白）。6周后处死动物。在组织学和显微断层扫描分析中，所有组均显示缺损边缘有骨生长，该区域无明显炎症过程，但E96/BMP组的骨板更厚，胶原纤维更有序。组织计量学分析显示，与其他组相比，该组新形成骨的百分比更高（43.25±3.72）。得出的结论是，由弹性蛋白基质与骨形态发生蛋白形成的支撑和递送系统对骨修复过程有积极作用。