有频繁和偶尔胃食管反流症状的受试者之间特征及疾病管理的比较研究
Comparative study of characteristics and disease management between subjects with frequent and occasional gastro-oesophageal reflux symptoms.
作者信息
Bretagne J F, Honnorat C, Richard-Molard B, Caekaert A, Barthélemy P
机构信息
Service des Maladies de l'Appareil Digestif, Hôpital Pontchaillou, Rennes, France.
出版信息
Aliment Pharmacol Ther. 2006 Mar 1;23(5):607-16. doi: 10.1111/j.1365-2036.2006.02811.x.
BACKGROUND
Little is known about the distinctive characteristics of subjects with frequent (at least weekly) and occasional gastro-oesophageal reflux symptoms.
AIM
To compare the characteristics and disease management of subjects complaining of at least weekly and less frequent gastro-oesophageal reflux symptoms.
METHODS
Population-based postal survey carried out in France in 2003 among a representative sample of 8000 subjects.
RESULTS
The prevalence of frequent and occasional gastro-oesophageal reflux symptoms was 7.8% and 23.4%, respectively. Compared to subjects with occasional gastro-oesophageal reflux symptoms, those with frequent symptoms were older, suffered from more severe symptoms and felt greater impact on daily living, despite a slightly shorter duration of symptoms. These subjects more often sought medical advice. Most of them had treated the last episode of symptoms primarily with a proton-pump inhibitor and less often with antacids/alginates. The degree of treatment satisfaction was lower in subjects with frequent gastro-oesophageal reflux symptoms, in relation to a more frequently observed persistence of symptoms irrespective of the medication used except for proton-pump inhibitors.
CONCLUSIONS
This survey suggests that subjects complaining of frequent or occasional gastro-oesophageal reflux symptoms constitute two distinctive groups. Despite greater healthcare use, the former group shows a lower level of satisfaction with disease management. Nevertheless, a substantial subset of subjects with occasional symptoms also complained of impaired health-related quality of life and sought health care.
背景
对于频繁(至少每周一次)和偶尔出现胃食管反流症状的患者的独特特征,人们了解甚少。
目的
比较主诉至少每周出现一次和较少出现胃食管反流症状的患者的特征及疾病管理情况。
方法
2003年在法国对8000名具有代表性的受试者进行了基于人群的邮寄调查。
结果
频繁和偶尔出现胃食管反流症状的患病率分别为7.8%和23.4%。与偶尔出现胃食管反流症状的患者相比,频繁出现症状的患者年龄更大,症状更严重,对日常生活的影响更大,尽管症状持续时间略短。这些患者更常寻求医疗建议。他们中的大多数人主要使用质子泵抑制剂治疗最后一次症状发作,较少使用抗酸剂/藻酸盐。频繁出现胃食管反流症状的患者的治疗满意度较低,这与无论使用何种药物(除质子泵抑制剂外)症状更频繁持续出现有关。
结论
这项调查表明,主诉频繁或偶尔出现胃食管反流症状的患者构成两个不同的群体。尽管前者使用医疗服务更多,但对疾病管理的满意度较低。然而,相当一部分偶尔出现症状的患者也抱怨与健康相关的生活质量受损并寻求医疗护理。