Service d'Hépato-Gastro-entérologie, CHU Robert Debré, Rue du Général Koenig, Reims Cedex, France.
Dig Liver Dis. 2011 Oct;43(10):784-7. doi: 10.1016/j.dld.2011.06.004. Epub 2011 Jul 12.
To evaluate the prevalence of sleep disturbances in French patients with gastro-oesophageal reflux disease and the impact of gastro-oesophageal reflux disease treatment on sleep.
A registry was compiled of all gastro-oesophageal reflux disease patients seen during a 2-week period by 1983 French primary care physicians. Data from the first two patients with nocturnal gastro-oesophageal reflux disease symptoms and gastro-oesophageal reflux disease-related sleep disturbances seen by each physician were derived from physician questionnaires and medical records. These patients completed a questionnaire during the initial consultation and after 1-month treatment.
A total of 33,391 patients were included in the study: physician questionnaires were available for 3269 patients and patient questionnaires for 2876. Nocturnal gastro-oesophageal reflux disease symptoms were reported by 21,337 patients (63.9%) and regular (at least once weekly) gastro-oesophageal reflux disease-related sleep disturbances by 19,313 (61.7%). Multivariate analysis showed that nocturnal gastro-oesophageal reflux disease symptoms, use of hypnotic drugs, and age over 50 years were significant independent predictors of sleep disturbances. The proportion of patients reporting at least one nocturnal gastro-oesophageal reflux disease symptom during the previous week decreased following treatment, from 98.8% to 39.3% (P<0.001).
Nocturnal gastro-oesophageal reflux disease symptoms are common in the French population and are associated with sleep disturbances. Effective treatment can significantly improve sleep duration and quality.
评估法国胃食管反流病患者睡眠障碍的流行情况以及胃食管反流病治疗对睡眠的影响。
通过 1983 年法国的 1983 名初级保健医生，收集了两周内所有胃食管反流病患者的资料。每位医生所观察到的前两名具有夜间胃食管反流病症状和与胃食管反流病相关的睡眠障碍的胃食管反流病患者的数据来自医生问卷和病历。这些患者在初次就诊时和治疗 1 个月后完成了一份问卷。
共有 33391 名患者纳入研究：3269 名患者的医生问卷可用，2876 名患者的患者问卷可用。21337 名患者（63.9%）报告有夜间胃食管反流病症状，19313 名患者（61.7%）有规律（每周至少一次）的与胃食管反流病相关的睡眠障碍。多变量分析表明，夜间胃食管反流病症状、使用催眠药物和年龄超过 50 岁是睡眠障碍的显著独立预测因素。治疗后，报告前一周至少有一次夜间胃食管反流病症状的患者比例从 98.8%降至 39.3%（P<0.001）。
夜间胃食管反流病症状在法国人群中很常见，与睡眠障碍有关。有效的治疗可以显著改善睡眠时长和质量。
