Kawai Takashi, Hirayama Yoji, Oguchi Aiko, Ishii Fumi, Matushita Masanao, Kitayama Naoya, Morishita Shinji, Hiratsuka Noboru, Ohata Ken, Konishi Hiroyuki, Kishino Maiko, Nakamura Shinichi
Gastroenterological Endoscopy, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
Department of General Medicine and Primary Care, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
J Clin Biochem Nutr. 2017 Mar;60(2):143-145. doi: 10.3164/jcbn.16-77. Epub 2017 Feb 8.
We investigated the effects of rikkunshito, in combination with a proton pump inhibitor, on symptoms and quality of life in patients with proton pump inhibitor-refractory gastroesophageal reflux disease. The subjects were 47 patients with gastroesophageal reflux disease with residual symptoms such as heartburn following 8 weeks of proton pump inhibitor therapy. We administered these subjects rikkunshito in combination with a proton pump inhibitor for 6-8 weeks. We scored their symptoms of heartburn, fullness, abdominal discomfort, and abdominal pain, and surveyed their quality of life using the Reflux Esophagitis Symptom Questionnaire, comprising questions concerning daily activities, meals (changes in amount and favorite foods), and sleep (getting to sleep and early morning waking). Improvement was seen in all symptoms, and quality of life scores for meals and sleep also improved. These results indicate that combination therapy with rikkunshito and a proton pump inhibitor improves quality of life related to eating and sleep in patients with patients with proton pump inhibitor-refractory gastroesophageal reflux disease.
我们研究了理气剂与质子泵抑制剂联合使用对质子泵抑制剂难治性胃食管反流病患者症状及生活质量的影响。研究对象为47例胃食管反流病患者，这些患者在接受质子泵抑制剂治疗8周后仍有烧心等残留症状。我们给予这些受试者理气剂与质子泵抑制剂联合治疗6 - 8周。我们对他们的烧心、饱胀、腹部不适和腹痛症状进行评分，并使用反流性食管炎症状问卷对他们的生活质量进行调查，该问卷包括有关日常活动、饮食（食量和喜爱食物的变化）以及睡眠（入睡和早醒）的问题。所有症状均有改善，饮食和睡眠的生活质量评分也有所提高。这些结果表明，理气剂与质子泵抑制剂联合治疗可改善质子泵抑制剂难治性胃食管反流病患者与饮食和睡眠相关的生活质量。
