de Jong A, Plat J, Mensink R P
Department of Human Biology, Maastricht University, Maastricht, The Netherlands.
Eur J Clin Nutr. 2006 Aug;60(8):985-90. doi: 10.1038/sj.ejcn.1602409. Epub 2006 Feb 15.
To assess the effects of plant sterol or stanol ester consumption on their incorporation into erythrocytes and their effects on osmotic fragility of red blood cells.
Double-blind, randomized, placebo-controlled intervention trial.
Forty-one subjects on stable statin treatment - who already have increased serum plant sterol and stanol concentrations - first received for 4 weeks a control margarine. For the next 16 weeks, subjects were randomly assigned to one of three possible interventions. Eleven subjects continued with control margarine, 15 subjects with plant sterol ester enriched and 15 subjects with plant stanol ester-enriched margarine. Daily plant sterol or stanol intake was 2.5 g. Erythrocyte haemolysis was measured spectrophotometrically at five different saline concentrations.
Despite significant (P = 0.004) increases of, respectively, 42 and 59% in cholesterol-standardized serum sitosterol and campesterol concentrations in the plant sterol group as compared to the control group, campesterol levels in the red blood cells did not change (P = 0.196). Osmotic fragility did not change significantly (P = 0.757) in the plant sterol and plant stanol groups as compared to the control group.
We conclude that plant sterol and stanol ester consumption for 16 weeks does not change osmotic fragility of erythrocytes in statin-treated patients.
Netherlands Organisation for Health Research and Development (Program Nutrition: Health, Safety and Sustainability, Grant 014-12-010).
评估食用植物甾醇或甾烷醇酯对其掺入红细胞的影响以及对红细胞渗透脆性的影响。
双盲、随机、安慰剂对照干预试验。
41名接受稳定他汀治疗的受试者——其血清植物甾醇和甾烷醇浓度已升高——首先接受4周的对照人造黄油。在接下来的16周里，受试者被随机分配到三种可能的干预措施之一。11名受试者继续食用对照人造黄油，15名受试者食用富含植物甾醇酯的人造黄油，15名受试者食用富含植物甾烷醇酯的人造黄油。每日植物甾醇或甾烷醇摄入量为2.5克。在五种不同的盐水浓度下，通过分光光度法测量红细胞溶血情况。
与对照组相比，植物甾醇组中胆固醇标准化血清谷甾醇和菜油甾醇浓度分别显著升高（P = 0.004）42%和59%，但红细胞中的菜油甾醇水平未发生变化（P = 0.196）。与对照组相比，植物甾醇组和植物甾烷醇组的渗透脆性没有显著变化（P = 0.757）。
我们得出结论，在接受他汀治疗的患者中，食用16周的植物甾醇和甾烷醇酯不会改变红细胞的渗透脆性。
荷兰卫生研究与发展组织（营养项目：健康、安全与可持续性，资助号014 - 12 - 010）。
