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1997 - 2003年明尼苏达州人源和动物源鼠伤寒沙门氏菌的抗菌药物敏感性

Antimicrobial-drug susceptibility of human and animal Salmonella typhimurium, Minnesota, 1997-2003.

作者信息

Wedel Stephanie D, Bender Jeffrey B, Leano Fe T, Boxrud David J, Hedberg Craig, Smith Kirk E

机构信息

Acute Disease Investigation and Control Section, Minnesota Department of Health, Minneapolis, Minnesota 55164-0975, USA.

出版信息

Emerg Infect Dis. 2005 Dec;11(12):1899-906. doi: 10.3201/eid1112.050158.

DOI:10.3201/eid1112.050158
PMID:16485477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3367623/
Abstract

We compared antimicrobial resistance phenotypes and pulsed-field gel electrophoresis (PFGE) subtypes of 1,028 human and 716 animal Salmonella enterica serotype Typhimurium isolates from Minnesota from 1997 to 2003. Overall, 29% of human isolates were multidrug resistant. Predominant phenotypes included resistance to ampicillin, chloramphenicol or kanamycin, streptomycin, sulfisoxazole, and tetracycline (ACSSuT or AKSSuT). Most human multidrug-resistant isolates belonged to PFGE clonal group A, characterized by ACSSuT resistance (64%), or clonal group B, characterized by AKSSuT resistance (19%). Most animal isolates were from cattle (n = 358) or swine (n = 251). Eighty-one percent were multidrug resistant; of these, 54% were at least resistance phenotype ACSSuT, and 43% were at least AKSSuT. More than 80% of multidrug-resistant isolates had a clonal group A or B subtype. Resistance to ceftriaxone and nalidixic acid increased, primarily among clonal group A/ACSSuT isolates. Clonal group B/AKSSuT isolates decreased over time. These data support the hypothesis that food animals are the primary reservoir of multidrug-resistant S. Typhimurium.

摘要

我们比较了1997年至2003年从明尼苏达州分离出的1028株人类和716株动物肠炎沙门氏菌鼠伤寒血清型菌株的抗菌药物耐药表型和脉冲场凝胶电泳（PFGE）亚型。总体而言，29%的人类分离株对多种药物耐药。主要表型包括对氨苄西林、氯霉素或卡那霉素、链霉素、磺胺异恶唑和四环素耐药（ACSSuT或AKSSuT）。大多数对多种药物耐药的人类分离株属于PFGE克隆群A，其特征为对ACSSuT耐药（64%），或克隆群B，其特征为对AKSSuT耐药（19%）。大多数动物分离株来自牛（n = 358）或猪（n = 251）。81%对多种药物耐药；其中，54%至少具有ACSSuT耐药表型，43%至少具有AKSSuT耐药表型。超过80%的对多种药物耐药的分离株具有克隆群A或B亚型。对头孢曲松和萘啶酸的耐药性增加，主要发生在克隆群A/ACSSuT分离株中。随着时间的推移，克隆群B/AKSSuT分离株减少。这些数据支持了食用动物是多重耐药鼠伤寒沙门氏菌主要储存宿主这一假设。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19e0/3367623/8cf3032a681f/05-0158-F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19e0/3367623/b0f5af631ad0/05-0158-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19e0/3367623/dbf72c09404d/05-0158-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19e0/3367623/7123f7628d01/05-0158-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19e0/3367623/8cf3032a681f/05-0158-F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19e0/3367623/b0f5af631ad0/05-0158-F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19e0/3367623/dbf72c09404d/05-0158-F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19e0/3367623/7123f7628d01/05-0158-F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19e0/3367623/8cf3032a681f/05-0158-F4.jpg

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