Veith Anne-Marie, Klattig Jürgen, Dettai Agnes, Schmidt Cornelia, Englert Christoph, Volff Jean-Nicolas
Department of Physiological Chemistry I, Biozentrum, University of Würzburg, Am Hubland, D-97074 Würzburg, Germany.
Genomics. 2006 Aug;88(2):185-95. doi: 10.1016/j.ygeno.2006.01.003. Epub 2006 Feb 20.
The vertebrate DMRT gene family encodes putative transcription factors related to the sexual regulators Doublesex (Drosophila melanogaster) and MAB-3 (Caenorhabditis elegans). They share a highly conserved DNA binding motif, the DM domain. In human and mouse seven DMRT genes (DMRT1-DMRT7) have been analyzed. DMRT8, a gene related to DMRT7, is located on the X chromosome in placental mammals. While DMRT8 is single copy in most mammals, three copies are present in mouse, rat, and rabbit. Despite the loss of the DM domain, DMRT8 genes have been maintained in the mammalian lineage, suggesting a DM domain-independent function. In adult mouse, two Dmrt8 genes are expressed exclusively in testis. Dmrt8.1 mRNA was detected in Sertoli cells by in situ hybridization. In embryos, Dmrt8.2 shows a dynamic expression restricted to male and female gonads and might therefore be involved in sexual development in the mouse.
脊椎动物的DMRT基因家族编码与性别调控因子双性基因（果蝇）和MAB - 3基因（秀丽隐杆线虫）相关的假定转录因子。它们共享一个高度保守的DNA结合基序，即DM结构域。在人类和小鼠中，已经分析了七个DMRT基因（DMRT1 - DMRT7）。与DMRT7相关的基因DMRT8位于胎盘哺乳动物的X染色体上。虽然DMRT8在大多数哺乳动物中是单拷贝的，但在小鼠、大鼠和兔子中存在三个拷贝。尽管DM结构域缺失，但DMRT8基因在哺乳动物谱系中得以保留，这表明其具有不依赖于DM结构域的功能。在成年小鼠中，两个Dmrt8基因仅在睾丸中表达。通过原位杂交在支持细胞中检测到了Dmrt8.1 mRNA。在胚胎中，Dmrt8.2表现出一种动态表达，仅限于雄性和雌性性腺，因此可能参与小鼠的性别发育。
