Wijeweera P, Arnason J T, Koszycki D, Merali Z
Ottawa-Carleton Institute of Biology, University of Ottawa Institute of Mental Health Research, Royal Ottawa Hospital, Canada.
Phytomedicine. 2006 Nov;13(9-10):668-76. doi: 10.1016/j.phymed.2006.01.011. Epub 2006 Feb 20.
The ayurvedic medicinal plant Gotukola (Centella asiatica) was evaluated for its anxiolytic properties. Specifically, this study assessed the effects of: Gotukola plant materials of different genotypic origin; hexane, ethyl acetate and methanol extracts of Gotukola; and asiaticoside, a triterpenic compound isolated from Gotukola. Various paradigms were used to assess the anxiolytic activity, including the elevated plus maze (EPM), open field, social interaction, locomotor activity, punished drinking (Vogel) and novel cage tests. The EPM test revealed that Gotukola, its methanol and ethyl acetate extracts as well as the pure asiaticoside, imparted anxiolytic activity. Furthermore, the asiaticoside did not affect locomotor activity, suggesting these compounds do not have sedative effects in rodents.
对阿育吠陀药用植物积雪草（Centella asiatica）的抗焦虑特性进行了评估。具体而言，本研究评估了以下各项的效果：不同基因型来源的积雪草植物材料；积雪草的己烷、乙酸乙酯和甲醇提取物；以及从积雪草中分离出的三萜化合物积雪草苷。使用了各种范例来评估抗焦虑活性，包括高架十字迷宫（EPM）、旷场试验、社交互动、自发活动、惩罚性饮水（Vogel）和新笼试验。EPM试验表明，积雪草及其甲醇和乙酸乙酯提取物以及纯积雪草苷具有抗焦虑活性。此外，积雪草苷不影响自发活动，表明这些化合物在啮齿动物中没有镇静作用。
