多种大环内酯类抗生素对小鼠麻风分枝杆菌感染的活性。
Activities of various macrolide antibiotics against Mycobacterium leprae infection in mice.
作者信息
Gelber R H, Siu P, Tsang M, Murray L P
机构信息
Kuzell Institute for Arthritis and Infectious Diseases, Medical Research Institute of San Francisco, California 94115-1896.
出版信息
Antimicrob Agents Chemother. 1991 Apr;35(4):760-3. doi: 10.1128/AAC.35.4.760.
Abstract
We evaluated the activities of several macrolide antibiotics against M. leprae infections in mouse footpads. Erythromycin and azithromycin were inactive, while both roxithromycin and clarithromycin were found to be consistently active and, in fact, bactericidal. By both methods, clarithromycin was found to be superior to roxithromycin, a finding which, at least in part, may be a consequence of the higher levels of clarithromycin at the site of infection.
摘要
我们评估了几种大环内酯类抗生素对小鼠足垫中麻风分枝杆菌感染的活性。红霉素和阿奇霉素无活性，而罗红霉素和克拉霉素均表现出持续的活性，事实上具有杀菌作用。通过两种方法均发现，克拉霉素优于罗红霉素，这一发现至少部分可能是由于感染部位克拉霉素水平较高所致。
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本文引用的文献
1
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2
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Am J Trop Med Hyg. 1971 Jul;20(4):616-20. doi: 10.4269/ajtmh.1971.20.616.
3
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Lepr Rev. 1985 Dec;56(4):265-78.
4
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5
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