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Kinetic testing of drugs against Mycobacterium leprae in mice. Activity of cephaloridine, rifampin, streptovaricin, vadrine, and viomycin.药物对小鼠麻风分枝杆菌的动力学测试。头孢菌素、利福平、链黑菌素、瓦屈林和紫霉素的活性。
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The killing of Mycobacterium leprae in mice by various dietary concentrations of dapsone and rifampicin.不同膳食浓度的氨苯砜和利福平对小鼠体内麻风分枝杆菌的杀灭作用。
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Activity of minocycline in Mycobacterium leprae-infected mice.米诺环素在感染麻风分枝杆菌小鼠中的活性。
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Oxidation of palmitic acid by Mycobacterium leprae in an axenic medium.麻风分枝杆菌在无细胞培养基中对棕榈酸的氧化作用。
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In vitro and in vivo activities of macrolides against Mycobacterium leprae.大环内酯类药物对麻风分枝杆菌的体外及体内活性
Antimicrob Agents Chemother. 1988 Dec;32(12):1758-62. doi: 10.1128/AAC.32.12.1758.

多种大环内酯类抗生素对小鼠麻风分枝杆菌感染的活性。

Activities of various macrolide antibiotics against Mycobacterium leprae infection in mice.

作者信息

Gelber R H, Siu P, Tsang M, Murray L P

机构信息

Kuzell Institute for Arthritis and Infectious Diseases, Medical Research Institute of San Francisco, California 94115-1896.

出版信息

Antimicrob Agents Chemother. 1991 Apr;35(4):760-3. doi: 10.1128/AAC.35.4.760.

DOI:10.1128/AAC.35.4.760
PMID:1648889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC245094/
Abstract

We evaluated the activities of several macrolide antibiotics against M. leprae infections in mouse footpads. Erythromycin and azithromycin were inactive, while both roxithromycin and clarithromycin were found to be consistently active and, in fact, bactericidal. By both methods, clarithromycin was found to be superior to roxithromycin, a finding which, at least in part, may be a consequence of the higher levels of clarithromycin at the site of infection.

摘要

我们评估了几种大环内酯类抗生素对小鼠足垫中麻风分枝杆菌感染的活性。红霉素和阿奇霉素无活性，而罗红霉素和克拉霉素均表现出持续的活性，事实上具有杀菌作用。通过两种方法均发现，克拉霉素优于罗红霉素，这一发现至少部分可能是由于感染部位克拉霉素水平较高所致。