白细胞介素-10在TH1和TH2反应交叉调节中的作用。
The role of IL-10 in crossregulation of TH1 and TH2 responses.
作者信息
Mosmann T R, Moore K W
机构信息
Dept of Immunology, University of Alberta, Edmonton, Canada.
出版信息
Immunol Today. 1991 Mar;12(3):A49-53. doi: 10.1016/S0167-5699(05)80015-5.
The identification of helper T (TH)-cell subsets has greatly improved understanding of the regulation of immune effector functions. In addition to controlling humoral and delayed-type hypersensitivity responses, these subsets crossregulate by secreting mutually inhibitory cytokines. In this review, Tim Mosmann and Kevin Moore examine these phenomena and in particular the role of interleukin 10, a cytokine secreted by TH2 cells that inhibits TH1-cell function.
辅助性T（TH）细胞亚群的鉴定极大地增进了人们对免疫效应功能调节的理解。除了控制体液免疫和迟发型超敏反应外，这些亚群还通过分泌相互抑制的细胞因子进行交叉调节。在这篇综述中，蒂姆·莫斯曼和凯文·穆尔研究了这些现象，尤其探讨了白细胞介素10的作用，白细胞介素10是一种由TH2细胞分泌的细胞因子，可抑制TH1细胞的功能。
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