白细胞介素-10在TH1和TH2反应交叉调节中的作用。

The role of IL-10 in crossregulation of TH1 and TH2 responses.

作者信息

Mosmann T R, Moore K W

机构信息

Dept of Immunology, University of Alberta, Edmonton, Canada.

出版信息

Immunol Today. 1991 Mar;12(3):A49-53. doi: 10.1016/S0167-5699(05)80015-5.

DOI:10.1016/S0167-5699(05)80015-5

PMID:1648926

Abstract

The identification of helper T (TH)-cell subsets has greatly improved understanding of the regulation of immune effector functions. In addition to controlling humoral and delayed-type hypersensitivity responses, these subsets crossregulate by secreting mutually inhibitory cytokines. In this review, Tim Mosmann and Kevin Moore examine these phenomena and in particular the role of interleukin 10, a cytokine secreted by TH2 cells that inhibits TH1-cell function.

摘要

辅助性T（TH）细胞亚群的鉴定极大地增进了人们对免疫效应功能调节的理解。除了控制体液免疫和迟发型超敏反应外，这些亚群还通过分泌相互抑制的细胞因子进行交叉调节。在这篇综述中，蒂姆·莫斯曼和凯文·穆尔研究了这些现象，尤其探讨了白细胞介素10的作用，白细胞介素10是一种由TH2细胞分泌的细胞因子，可抑制TH1细胞的功能。