Rojansky N, Halbreich U, Zander K, Barkai A, Goldstein S
Department of Obstetrics and Gynecology, State University of New York, Buffalo.
Gynecol Obstet Invest. 1991;31(3):146-52. doi: 10.1159/000293135.
Gonadal hormones are believed to be involved in the pathophysiology of premenstrual changes (PMC) possibly through their interaction with neurotransmitter systems in the brain. The serotonergic system, an important central modulator of mood and behavior which is involved in the pathophysiology of affective disorders has been suggested to play a role in the genesis of dysphoric PMC. Blood platelet serotonin (5-HT) uptake and imipramine (IMI) binding have been shown to share similarities with serotonergic mechanisms in the brain thus enabling the study of serotonergic mechanisms. In this study, we report on platelet 5-HT uptake and IMI receptor binding which were simultaneously studied in women with PMC. Subjects with PMC showed a large interindividual variability with no consistent typical pattern or change during the late symptomatic as compared to the early nonsymptomatic luteal phase. Their IMI receptor binding, however, was lower compared to controls already during the early luteal phase before they developed symptoms and was similar during the symptomatic phase. This might suggest a preexistent vulnerability to the development of dysphoric PMC that might be related to impaired gonadal hormone modulation of the serotonergic system.
性腺激素被认为可能通过与大脑中的神经递质系统相互作用，参与经前变化（PMC）的病理生理过程。血清素能系统是情绪和行为的重要中枢调节因子，参与情感障碍的病理生理过程，有人认为它在烦躁性经前变化的发生中起作用。血小板血清素（5 - HT）摄取和丙咪嗪（IMI）结合已被证明与大脑中的血清素能机制有相似之处，从而能够对血清素能机制进行研究。在本研究中，我们报告了对患有PMC的女性同时进行的血小板5 - HT摄取和IMI受体结合情况。与早期无症状的黄体期相比，患有PMC的受试者在症状后期表现出较大的个体间差异，没有一致的典型模式或变化。然而，她们的IMI受体结合在出现症状前的黄体早期就已经低于对照组，在症状期则相似。这可能表明存在对烦躁性PMC发展的预先易感性，这可能与性腺激素对血清素能系统调节受损有关。
