Bastani B, Arora R C, Meltzer H Y
Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Biol Psychiatry. 1991 Jul 15;30(2):131-9. doi: 10.1016/0006-3223(91)90166-j.
14C-Serotonin (5-HT) uptake and 3H-imipramine binding (IB) were studied in the blood platelets of 20 obsessive-compulsive disorder (OCD) patients, 53 normal controls (5-HT uptake) and 32 normal controls (IB binding). The maximum number of binding sites (Bmax) was significantly decreased in OCD patients compared to normal controls, but there was no difference in the affinity for 3H-imipramine (Kd). The affinity for 5-HT uptake (Km) was also decreased in the OCD patients but the maximum velocity of 5-HT uptake sites (Vmax) was not significantly different in OCD patients and normal volunteers. There were trends for the Slowness Subscale of the Maudsley Obsessional-Compulsive Inventory (MOCI) to be positively correlated with the Km of 5-HT uptake (p = 0.094), whereas the Global Scale, Checking Subscale, and Doubting Conscientiousness Subscale of MOCI were negatively correlated with the Kd of IB (p = 0.066, p = 0.08, and p = 0.062, respectively). The results provide further evidence for the dysfunction of the serotonergic system in OCD.
在20名强迫症（OCD）患者、53名正常对照者（用于5-羟色胺摄取研究）和32名正常对照者（用于3H-丙咪嗪结合研究）的血小板中，对14C-5-羟色胺（5-HT）摄取和3H-丙咪嗪结合（IB）进行了研究。与正常对照相比，强迫症患者的最大结合位点数（Bmax）显著降低，但对3H-丙咪嗪的亲和力（Kd）无差异。强迫症患者对5-HT摄取的亲和力（Km）也降低，但5-HT摄取位点的最大速度（Vmax）在强迫症患者和正常志愿者中无显著差异。Maudsley强迫观念-强迫行为量表（MOCI）的迟缓分量表有与5-HT摄取的Km呈正相关的趋势（p = 0.094），而MOCI的总体量表、检查分量表和怀疑尽责分量表与IB的Kd呈负相关（分别为p = 0.066、p = 0.08和p = 0.062）。这些结果为强迫症中血清素能系统功能障碍提供了进一步的证据。
