Weizman A, Carmi M, Hermesh H, Shahar A, Apter A, Tyano S, Rehavi M
Am J Psychiatry. 1986 Mar;143(3):335-9. doi: 10.1176/ajp.143.3.335.
The authors evaluated high-affinity [3H]imipramine binding and [3H]serotonin uptake to platelets in eight adolescent and 10 adult patients who met DSM-III criteria for obsessive-compulsive disorder in comparison with those of normal control subjects of similar ages. The maximal binding of [3H]imipramine was significantly lower in adults and adolescents with obsessive-compulsive disorder than in the control subjects. No differences between groups in the affinity of [3H]imipramine to its binding sites or in serotonin uptake kinetic measures were detected. The lower density of [3H]imipramine binding sites in platelet membrane in patients with obsessive-compulsive disorder might implicate involvement of the serotonergic system or might represent an adaptive response to a chronic disease.
作者评估了8名青少年和10名成年强迫症患者的血小板对高亲和力[3H]丙咪嗪的结合及[3H]5-羟色胺摄取情况，并与年龄相仿的正常对照者进行比较，这些患者均符合《精神疾病诊断与统计手册》第三版（DSM-III）的强迫症诊断标准。成年和青少年强迫症患者的[3H]丙咪嗪最大结合量显著低于对照者。未检测到各组间[3H]丙咪嗪与其结合位点的亲和力或5-羟色胺摄取动力学指标存在差异。强迫症患者血小板膜中[3H]丙咪嗪结合位点密度较低，这可能意味着5-羟色胺能系统参与其中，或者可能代表对慢性疾病的一种适应性反应。
