Hanssen M, Krabbendam L, Vollema M, Delespaul P, Van Os J
Department of Psychiatry and Neuropsychology, EURON, Maastricht University, Maastricht, The Netherlands.
J Abnorm Psychol. 2006 Feb;115(1):5-14. doi: 10.1037/0021-843X.115.1.5.
It is unknown to what degree dimensions of schizotypy (subclinical psychosis) show independent, family-specific variation in the general population. Psychologists administered the Community Assessment of Psychic Experiences, the Structured Interview for Schizotypy-Revised (SIS-R), and the Brief Psychiatric Rating Scale to 257 subjects pertaining to 82 general population families. All 3 instruments showed family-specific variation for positive and negative subclinical psychosis dimensions with between-families proportions of total variance between 10% and 40%. However, only the SIS-R showed family-specific variation of the negative dimension independent of its correlation with the positive dimension. The positive dimension of subclinical psychosis shows familial-specific variation in samples unselected for psychiatric disorder, suggesting dimensional liability in the population. The SIS-R additionally captures family-specific variation in the negative domain.
目前尚不清楚精神分裂症型人格（亚临床精神病）的维度在普通人群中在何种程度上表现出独立的、家族特异性的变异。心理学家对来自82个普通人群家庭的257名受试者进行了精神体验社区评估、精神分裂症型人格结构化访谈修订版（SIS-R）和简明精神病评定量表测试。所有这三种工具都显示出阳性和阴性亚临床精神病维度的家族特异性变异，家族间总方差比例在10%至40%之间。然而，只有SIS-R显示出阴性维度的家族特异性变异，且独立于其与阳性维度的相关性。亚临床精神病的阳性维度在未因精神疾病而被选择的样本中表现出家族特异性变异，这表明人群中存在维度易感性。SIS-R还额外捕捉到了阴性领域的家族特异性变异。
