Brennan S C, McLaughlin M K, Chez R A
Am J Obstet Gynecol. 1977 Aug 1;128(7):709-15. doi: 10.1016/0002-9378(77)90708-6.
We have extended our evaluation of the effects of three beta-adrenergic agents in near-term pregnant sheep to include a period of infusion three times longer than previously studied. This extension has provided the following information: (1) Initial depression of uterine blood flow and mean arterial pressure associated with administration of ritodrine or salbutamol abate with time despite continued drug infusion; (2) the uterine hyperemia associated with salbutamol and fenoterol are drug-related rather than postinfusion-related phenomena; (3) increased uterine vascular resistance is found with ritodrine, and decreased uterine vascular resistance occurs with salbutamol and fenoterol.
我们将对三种β-肾上腺素能药物对近足月妊娠绵羊影响的评估时间延长至此前研究时长的三倍。这一延长带来了以下信息：（1）尽管持续输注药物，但与使用利托君或沙丁胺醇相关的子宫血流量和平均动脉压的初始降低会随时间减轻；（2）与沙丁胺醇和非诺特罗相关的子宫充血是与药物相关而非输注后相关的现象；（3）利托君会使子宫血管阻力增加，而沙丁胺醇和非诺特罗会使子宫血管阻力降低。
