Hasaart T H, de Haan J
Department of Obstetrics and Gynecology, Annadal Hospital, State University Limburg, Maastricht, The Netherlands.
J Perinat Med. 1987;15(6):523-9. doi: 10.1515/jpme.1987.15.6.523.
The results from studies on the reactions of the uterine vascular bed upon intravenous administrations of beta-adrenergic drugs to the ewe are not all identical. This can be partly explained by different reactions of the pelvic vasculature on beta-adrenergic receptor stimulation. In order to assess whether any differences in flow reactions existed between the vascular beds of two maternal pelvic vessels upon beta-adrenergic receptor stimulation, we studied the effect of continuous maternal intravenous infusion with fenoterol on the blood flow in the maternal internal iliac and the median uterine artery in seven chronically instrumented pregnant sheep between 104 and 142 days gestation. Furthermore, the effects on umbilical venous blood flow, fetal heart rate, blood pressure and acid-base balance were analyzed. Maternal and fetal blood flows were measured with electromagnetic flow transducers. Fenoterol was administered to the ewe via a continuous intravenous infusion in two sequential periods of 30 minutes duration in a dose of 2 respectively 4 micrograms per minute. The blood flow in the internal iliac artery showed an increase of 10.5% (p less than 0.05) at the end of the infusion period and was still but not significantly elevated during the postinfusion period. No significant changes in median uterine artery blood flow were found during the fenoterol infusion, although an incremental trend was present. Fenoterol infusion to the mother had no effect on umbilical venous blood flow. Fetal pH and PO2 did not change, while fetal PCO2 was reduced (p less than 0.005) at the end of the infusion and recovery period, probably as a result of the concomitant maternal hyperventilation.(ABSTRACT TRUNCATED AT 250 WORDS)
关于给母羊静脉注射β-肾上腺素能药物后子宫血管床反应的研究结果并不完全相同。这部分可以通过盆腔血管系统对β-肾上腺素能受体刺激的不同反应来解释。为了评估在β-肾上腺素能受体刺激下，母羊两条盆腔血管的血管床之间血流反应是否存在差异，我们研究了在妊娠104至142天的7只长期植入仪器的怀孕绵羊中，持续静脉输注非诺特罗对母羊髂内动脉和子宫中动脉血流的影响。此外，还分析了对脐静脉血流、胎儿心率、血压和酸碱平衡的影响。母羊和胎儿的血流用电磁流量传感器测量。非诺特罗通过持续静脉输注给予母羊，分两个连续的30分钟时间段，剂量分别为每分钟2微克和4微克。输注期结束时，髂内动脉血流增加了10.5%（p<0.05），输注后仍有升高但不显著。在非诺特罗输注期间，子宫中动脉血流未发现显著变化，尽管有增加的趋势。给母体输注非诺特罗对脐静脉血流没有影响。胎儿的pH值和PO2没有变化，而胎儿PCO2在输注和恢复期结束时降低（p<0.005），这可能是由于母体同时出现的过度通气所致。（摘要截断于250字）
