Chan David P L, Teoh Stephen C B, Tan Colin S H, Nah Gerard K M, Rajagopalan Rajesh, Prabhakaragupta Manjunath K, Chee Caroline K L, Lim Tock H, Goh Kong Y
The Eye Institute at Tan Tock Seng Hospital, Singapore, Republic of Singapore.
Emerg Infect Dis. 2006 Feb;12(2):285-9. doi: 10.3201/eid1202.050274.
We report 13 cases of ophthalmic complications resulting from dengue infection in Singapore. We performed a retrospective analysis of a series of 13 patients with dengue fever who had visual impairment. Investigations included Humphrey automated visual field analyzer, Amsler charting, fundus fluorescein angiography, and optical coherence tomography. Twenty-two eyes of 13 patients were affected. The mean age of patients was 31.7 years. Visual acuity varied from 20/25 to counting fingers only. Twelve patients (92.3%) noted central vision impairment. Onset of visual impairment coincided with the nadir of serum thrombocytopenia. Ophthalmologic findings include macular edema and blot hemorrhages (10), cotton wool spots (1), retinal vasculitis (4), exudative retinal detachment (2), and anterior uveitis (1). All patients recovered visual acuity to 20/30 or better with residual central scotoma by 12 weeks. These new complications suggest a widening spectrum of ophthalmic complications in dengue infection.
我们报告了新加坡13例由登革热感染导致的眼科并发症。我们对一系列13例患有视力障碍的登革热患者进行了回顾性分析。检查包括 Humphrey 自动视野分析仪、Amsler 图表检查、眼底荧光血管造影和光学相干断层扫描。13例患者的22只眼睛受到影响。患者的平均年龄为31.7岁。视力从20/25到仅能数指不等。12例患者（92.3%）出现中心视力损害。视力损害的发作与血清血小板减少的最低点同时出现。眼科检查结果包括黄斑水肿和片状出血（10例）、棉絮斑（1例）、视网膜血管炎（4例）、渗出性视网膜脱离（2例）和前葡萄膜炎（1例）。所有患者在12周时视力恢复到20/30或更好，但仍有残留的中心暗点。这些新的并发症表明登革热感染导致的眼科并发症范围正在扩大。
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