Zhao Ping, Wang Jiang-bin, Jiao Jian
Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun 130033, China.
Zhonghua Gan Zang Bing Za Zhi. 2006 Feb;14(2):86-8.
To investigate the incidence of type 2 diabetes mellitus in patients with chronic hepatitis C (CHC) and its relation to HCV genotypes, and to confirm whether diabetes is an exohepatic manifestation of CHC.
Sandwich hybridization microplate assays and fluorescence quantification PCR technology were used to detect HBV DNA, HCV RNA and HCV genotypes of 308 chronic hepatitis C patients and 305 chronic hepatitis B patients. The incidence of diabetes in these patients was compared and analyzed with that in 310 controls.
The incidence of diabetes in patients with chronic hepatitis C was 32.79%, higher than that in patients with chronic hepatitis B (9.84%) and in the control group (8.39%). Serum levels of ALT and TBIL in hepatitis C patients with diabetes were higher than those without diabetes. Infection rate of HCV 1b in hepatitis C patients with diabetes was the highest (40.59%), and when compared with that of those without diabetes the difference was very significant.
Incidence of diabetes mellitus in patients with chronic hepatitis C is high, especially those infected with HCV 1b, and the liver functions of these patients are more severely damaged.
探讨慢性丙型肝炎（CHC）患者2型糖尿病的发病率及其与HCV基因型的关系，并证实糖尿病是否为CHC的肝外表现。
采用夹心杂交微孔板法和荧光定量PCR技术检测308例慢性丙型肝炎患者和305例慢性乙型肝炎患者的HBV DNA、HCV RNA及HCV基因型。将这些患者的糖尿病发病率与310例对照者进行比较分析。
慢性丙型肝炎患者的糖尿病发病率为32.79%，高于慢性乙型肝炎患者（9.84%）和对照组（8.39%）。糖尿病丙型肝炎患者的血清ALT和TBIL水平高于无糖尿病者。糖尿病丙型肝炎患者中HCV 1b的感染率最高（40.59%），与无糖尿病者相比差异非常显著。
慢性丙型肝炎患者糖尿病发病率高，尤其是感染HCV 1b者，且这些患者的肝功能损害更严重。
